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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel Glycosaminoglycan Ethers for Prevention of Metastasis

    SBC: GLYCOMIRA, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Heparin and its derivatives block P- and L-selectin mediated metastatic spread of cancer in animal models, and they potently inhibit the matrix degrading enzyme heparanase. Moreover, several large clinical trials performed with heparin or low molecular weight heparin have shown that survival is significantly improved by daily subcutaneous administration of hepa ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Unique Opioid Analgesics With No Addiction Liability or Dysphoria

    SBC: PHOENIX PHARMALABS, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): This Phase I application requests funds to support the continued preclinical evaluation of a novel opioid analgesic, PPL-103, and the synthesis and initial preclinical evaluation of a series of new analogs thereof.PPL-103, a potent analgesic, has undergone early preclinical studies by Phoenix PharmaLabs, Inc. (PPL), the applicant organization, and NIDA. PPL ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis

    SBC: GLYCOMIRA, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Chronic gingival inflammation afflicts over half of all American adults and can progress to periodontal disease, eventually resulting in tooth loss. Periodontitis is initiated by bacterial infection of the gingival tissues through a subgingival microbial biofilm on the tooth surface that releases bacterial lipopolysaccharide (LPS) and other antigens. In turn, L ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation

    SBC: GLYCOMIRA, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Painful bladder syndrome/interstitial cystitis (PBS/IC) is an indolent bladder disorder that has continued to be a debilitating disease with few truly effective treatment options. Inflammatory conditions that afflict the urinary bladder can lead to pelvic pain, debilitating urinary symptoms, bladder fibrosis, recurring urinary infection, and renal failure. We h ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Development and Commercialization of Next Generation of Neural Microelectrode Arr

    SBC: BLACKROCK MICROSYSTEMS            Topic: NINDS

    DESCRIPTION (provided by applicant): The array technology developed by Normann et.al. two decades ago at the University of Utah is currently being manufactured and marketed to the neuroscience research community by Blackrock Microsystems (formerly known asCyberkinetics, Inc., CKI). The Utah electrode array (UEA) is the only high- electrode density, penetrating microelectrode array that is FDA and ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Implantable Myoelectric Recording Array for Control of Prostheses

    SBC: RIPPLE, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): The goal of this translational SBIR program is to create a small, implantable system for recording myoelectric signals from residual and reinnervated muscles of individuals with forearm and other amputations. The signals will be wirelessly coupled to an external receiver for controlling prostheses. Compared to conventional surface electrodes, this system will p ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Backbone Degradable Polymer-drug Conjugates for the Treatment of Ovarian Cancer

    SBC: TheraTarget, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): This Phase I proposal details the rationale and the research plan for the synthesis and characterization of targeted, backbone degradable, long-circulating polymer conjugates containing two anticancer drugs per macromolecule. The polymeric carrier will be composed of alternating N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer segments (blocks) and enzymatica ...

    STTR Phase I 2011 Department of Health and Human Services
  8. Development of novel adenosine polymers for coating medical devices

    SBC: NUVIEW LIFE SCIENCES, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Percutaneous coronary intervention (PCI) is the most frequently employed strategy to revascularize atherosclerotic stenosis of native coronary arteries and saphenous vein grafts. Tissue perfusion is frequently impairedfollowing PCI, particularly in patients with ST segment elevation myocardial infarction (STEMI). This results in the no-reflow phenomenon which ...

    STTR Phase I 2011 Department of Health and Human Services
  9. Autonomous Power Management for Hearing Aids and Hearing Products

    SBC: PACKET DIGITAL LLC            Topic: NIDCD

    DESCRIPTION (provided by applicant): Loss of hearing affects the quality of life for individuals. The number of Americans with hearing loss is increasing as baby boomers age and younger citizens damage their hearing with personal audio devices. By 2025, approximately 40 million Americans are projected to be hearing impaired, an increase of 23% from current numbers. Hearing loss may be treated, but ...

    SBIR Phase II 2011 Department of Health and Human Services
  10. Physiological Controller for Rotary Blood Pumps

    SBC: WORLD HEART CORPORATION            Topic: NHLBI

    DESCRIPTION (provided by applicant): Competing Continuation Grant Application Physiologic Controller for Rotary Blood Pumps Rotary blood pumps are rapidly gaining favor in the field of mechanical circulatory support because of their small size, reliability, and energy efficiency. However the control of these pumps presents some difficulties because of their sensitivity to circulatory load and ab ...

    SBIR Phase II 2011 Department of Health and Human Services

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