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This proposal describes the feasibility and design study of a system for detection and imaging light and dense non aqueous phase liquids (so called LNAPLs and DNAPOLs) that have contaminated soils and aquifers. The system will make use of several modalities to improve combined spatial resolution and selectivity for detecting and imaging aquifers, LNAPLs and DNAPOLs. To accomplish a broader spect ...

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Systems & Processes Engineering Corp. (SPEC) proposed the development of a GaAs Field Programmable Gate Array (FPGA) for spaceborne applications. Digital Gate Array ICs combine functions of many logic gates into a single chip to improve speed, weight, and power dissipation. Field programmable gate arrays reduce cost to first functional chip by an order of magnitude. Presently no FPGAs are quali ...

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Genetic manipulation is a developing tool in cardiovascular research, and much of this work isdone in mice. Ultrasound equipment designed for use on humans is not suitable for non-invasivemonitoring of cardiovascular parameters in mice due to small organ size (5 mm dia heart) and high heartrates (400-600 bpm). We propose to develop an instrument to measure cardiac output and myocardialfunction non ...

Magnetic resonance imaging (MRI) is a powerful tool for the diagnosis of a broad range of clinicalconditions. Expensive contrast media (about $110.00/dose) contribute to its high cost. We will performthe preliminary steps necessary for a pre-IND evaluation by the FDA of a new inexpensive agent,Gadolinium DTPA Bisglucosamide. Preliminary investigations show lower animal toxicity, improvedgadolinium ...

The thrust of this proposal is the development of small, economical, table-top accelerators for thethe short-lived radioisotopes for the powerful medical diagnostic techniques, based on positron emis(PET), which have proven effective in monitoring physiological processes in the body, including braivisual processing. It draws upon recent advances in linear accelerator technology, a new rf-focusedst ...

Nonisotopic calorimetric and chemiluminescent technologies will be developed for use withribonuclease protection assays. The ribonuclease protection assay is an increasingly utilized techniquein molecular biology affording sensitive and quantitative measurement of mRNA levels. The ability ofthe assay to detect multiple mRNA levels simultaneously makes this technique a unique and powerfultool for u ...

We propose developing a diode laser-based full-spectrum Raman scattering instrument prototype incorporating fiberoptic coupling for rapid, continuous on-line and remote monitoring of fuels. Raman's narrow, well-defined peaks and its insensitivity to moisture contamination allow for full-spectrum detection with 0.1% sensitivity for liquids and with 30 to 60 second response times. Traditional Raman ...