Award Data

DESCRIPTION (provided by applicant): Phenylketonuria (PKU) is a genetic deficiency of phenylalanine hydroxylase (PAH). Without PAH, the patient with PKU cannot metabolize phenylalanine (PHE) to tyrosine. The resulting accumulation of PHE and the accumulation of phenylpyruvate by a secondary metabolic pathway in the patient's blood produce neuropathies including severe mental retardation, behavior ...

The accurate measurement of blood glucose concentration is important in the management of diabetes. Current methods of glucose monitoring involve piercing the skin and collecting blood samples for analysis up to four times daily or more. Even the non-invasive Glucowatch tm glucose monitoring system requires twice daily blood collection for calibration. This original, innovative invention will decr ...

A SMALLER, LIGHTER, MORE EFFICIENT, AND MORE RELIABLE CLINICAL GAS ANALYZER FOR RESPIRATORY AND ANESTHETIC GAS MONITORING IS NEEDED. EXISTING LASER RAMAN-BASED INSTRUMENTATION USES A LARGE, HEAVY, AND EXTREMELY INEFFICIENT (0.1 PERCENT) ARGON ION LASER WITH AN INTRACAVITY GAS CELL. THE LONG-TERM OBJECTIVE OF THIS STUDYIS TO IMPLEMENT A SOLID-STATE ALTERNATIVE TO THE EXISTING ION LASER. SUCH A LASE ...

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DESCRIPTION (provided by applicant): Multiple studies have established that bright light therapy is effective in alleviating symptoms of winter depression (seasonal affective disorder, or SAD). Light units used for treating SAD in the past have generally emitted polychromatic white light of highly variable spectral properties. Although several studies have attempted to test the effectiveness of ...

We have developed a transdominant genetic methodology for isolating peptide, protein or RNA factors (collectively called peturbagens) that modulate biochemical targets within a cell to alter its phenotype. Because it is genetic approach, it can be applied in both the classical forward mode (from phenotype to genotype) to reverse mode (from gene to function). The main goal of the proposed Phase I r ...

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There are many data acquisition systems available for neuroscientists interested in multi-channel neurophysiology but all use proprietary, independently-developed file formats for the acquired data. This creates several problems including difficulties in sharing data between laboratories and poor interoperability between equipment, data processing tools and spike classification software from diffe ...

There are many data acquisition systems available for neuroscientists interested in multi-channel neurophysiology but all use proprietary, independently-developed file formats for the acquired data. This creates several problems including difficulties in sharing data between laboratories and poor interoperability between equipment, data processing tools and spike classification software from diffe ...

We propose to isolate and identify novel AMPA receptor blocking conopeptides from marine cone snail venom for chronic pain intervention. Conopeptides are bioactive peptides from marine cone snail venom, and AMPA (a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors are non-NMDA glutamate type receptors, which mediate fast signal transmission in nociceptive pathways. AMPA receptor blocki ...