Award Data

A SMALLER, LIGHTER, MORE EFFICIENT, AND MORE RELIABLE CLINICAL GAS ANALYZER FOR RESPIRATORY AND ANESTHETIC GAS MONITORING IS NEEDED. EXISTING LASER RAMAN-BASED INSTRUMENTATION USES A LARGE, HEAVY, AND EXTREMELY INEFFICIENT (0.1 PERCENT) ARGON ION LASER WITH AN INTRACAVITY GAS CELL. THE LONG-TERM OBJECTIVE OF THIS STUDYIS TO IMPLEMENT A SOLID-STATE ALTERNATIVE TO THE EXISTING ION LASER. SUCH A LASE ...

N/A

FLOW/STERIC FIELD-FLOW FRACTIONATION (FLOW/STFFF) IS A RECENTLY DEVELOPED METHOD WITH EXTRAORDINARY SPEED AND RESOLVING POWER DESIGNED TO SEPARATE PARTICULATE MATERIALS FALLING ROUGHLY IN THE 1 TO 100 MUM PARTICLE DIAMETER RANGE. THE OBJECT OF THIS PROJECT IS TO EXAMINE THE POTENTIAL OF CONVERTING THIS RESEARCH FINDING INTO A FAST AND RELIABLE TOOL FOR THE FRACTIONATION AND CHARACTERIZATIONOF CELL ...

FREE TISSUE TRANSFER HAS REVOLUTIONIZED MANY AREAS OF RECONSTRUCTIVE SURGERY. AS FREE TISSUE TRANSFER IS NOW BEING DONE ROUTINELY AT INSTITUTIONS WHERE INEXPERIENCED STAFF ARE UNABLE TO ADEQUATELY MONITOR VIABILITY, THE NEED FOR A RELIABLE METHOD TO MONITOR THE PATENCY OF MICROVASCULAR ANASTOMOSES HAS BECOME INCREASINGLY EVIDENT. ACCURATE MONITORING OF BLOOD FLOW DURING AND AFTER SURGERY IS ESSENT ...

THE APPLICATION OF PHYSICAL-CHEMICAL PRINCIPLES TO BIOLOGICAL SYSTEMS FREQUENTLY LEADS TO SITUATIONS IN WHICH THE QUANTITATIVE TREATMENT OF CONCEPTUALLY SIMPLE MODELS IS CONFOUNDED BY THE COMPLEXITY OF THE SYSTEM. SUCH IS THE CASE, FOR EXAMPLE, IN THE STUDY OF THE PERMEATION (AND POSSIBLE CONCURRENT METABOLISM) OF DRUGS THROUGH COMPLEX BIOLOGICAL MEMBRANES, THE PHYSIOLOGICAL MODELING OF THE DISTRI ...

RECENT INNOVATIONS IN MOTION-CONTROL TECHNOLOGY HAVE THE POTENTIAL TO PROVIDE THE VIABLE DESIGN AND DEVELOPMENT OF A PORTABLE, LIGHTWEIGHT, COMPUTER-CONTROLLED MULTIVANE COLLIMATOR THAT CAN BE USED SIMPLY AND EASILY IN TYPICAL RADIATION THERAPY FACILITIES, AS A THERAPY MACHINE ACCESSORY, TO PROVIDE IMPROVED DOSE UNIFORMITY IN ELECTRON ARC THERAPY. A PROTOTYPE MULTIVANE COLLIMATOR HAS BEEN COMPLETE ...

N/A

TECHNICAL RESEARCH ASSOCIATES, INC. PROPOSES THE DEVELOPMENTOF A NOVEL PLATELET-HARVESTING SYSTEM BASED ON A PREVIOUSLY DEVELOPED ULTRASOUND SEPARATION TECHNOLOGY. THIS TECHNOLOGY, DEVELOPED UNDER AN NHLBI GRANT, ALLOWS THE SEQUENTIAL SEPARATION OF CELLS BASED ON THEIR SIZE, EVEN THOSE CELLS THAT HAVE IDENTICAL DENSITIES. FIRST, RESIDUAL ERYTHROCYTES AND LARGE LEUKOCYTES CAN BE SEPARATED FROM PLAT ...

THE OVERALL OBJECTIVE OF THIS PROJECT IS TO DESIGN AN APPARATUS AND PROCEDURE TO EXTEND THE VITALITY OF STORED HUMAN PLATELET CONCENTRATES FOR TRANSFUSION. EXPERIMENTS WILL BE CONDUCTED THAT WILL SIMULATE THE CONDITION OF MICROGRAVITY STORAGE AND AT THE SAME TIME KEEP MOST OF THE PLATELETS AWAY FROM THE BAG WALLS USING ULTRASOUND. OTHER EXPERIMENTS WILL INVESTIGATE THE EFFECT OF PLATELET/WALL INTE ...

THIS PROJECT WILL DEVELOP A UNIQUE ANIMAL IDENTIFICATION SYSTEM CONSISTING OF A PASSIVE IMPLANTABLE AND A HAND-HELD ACTIVE SENSOR DEVICE. PHASE I DEVELOPMENT WILL FOCUS ON AN INITIAL INVESTIGATION OF THE IMPLANTABLE'S CHARACTERISTICS WITH A SECONDARY EFFORT TO DESIGN THE SENSOR CIRCUITRY. SMALL RATS WILL BE USED TO STUDY THE ACUTE EFFECTS OF TAG PLACEMENT AND TO ASCERTAIN THE PROBABLE MIGRATION DY ...