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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. OVERHEAD INFRARED VEHICLE DETECTOR

    SBC: Schwartz Electro-Optics, Inc            Topic: N/A

    THE SHORTCOMINGS OF THE WIDELY USED BURIED-LOOP VEHICLE DE- TECTOR -- 3 TO 5 YEAR LIFETIME, COSTLY, INCONVENIENT TO MAINTAIN/REPLE, INCOMPATIBLE WITH SOME ROADWAYS, UNRELIABLE ACTIVATION BY SOME VEHICLES -- CAN BE OVERCOME THROUGH THE USE OF OVERHEAD INFRARED VEHICLE DETECTORS. THE TECHNICAL OBJECTIVES OF THE PROPOSED RESEARCH INCLUDE A SURVEY OF APPROPRIATE INFRARED SENSORS AND DEVICE ANALYSIS, D ...

    SBIR Phase II 1989 Department of Transportation
  2. ENZYME-TARGETED ANTIMICROBIALS FOR PLANT DISEASE CONTROL

    SBC: Metagene Corp.            Topic: N/A

    NO MICROBIOCIDE IS AVAILABLE THT IS EFFECTIVE AGAINST SUCH MAJOR PHYTOPATHOGENS AS SPECIES OF XANTHOMONAS, ERWINIA AND PSEUDOMONAS SYRINGAE. THESE PROKARYOTE PATHOGENS POSSESS A BIOCHEMICA PATHWAY FOR BIOSYNTHESIS OF AMINO ACIDS THAT CON-TAINS ENZYMES WHICH HAVE IDEAL POTENTIAL AS TARGETS FOR ANTIMICROBIAL ATTACK. PROSPECTS FOR SELECTIVE ACTION AGAINST THE BACTERIAL PATHOGEN AND NOT THE PLANT HOST ...

    SBIR Phase II 1989 Department of Agriculture
  3. MOLECULAR ANALYSIS OF TK AND HPRT GENE MUTATIONS IN L5178Y MOUSE LYMPHOMA CELLS

    SBC: APPLIED GENETICS LABORATORIES            Topic: N/A

    APPLIED GENETICS LABORATORIES, INC. PROPOSES TO UTILIZE NEWLY DEVELOPED MOLECULAR GENETIC TECHNIQUES TO ANALYZE THE SPECTRUM OF MUTAGENIC EVENTS THAT OCCUR AT THE TK AND HPRT LOCI IN MOUSE L5178Y CELLS. THE PURPOSE OF THESE STUDIES ISTO DETERMINE IF THE SPECTRUM OF GENETIC ABNORMALITIES REGISTERED AT THESE LOCI IS A FUNCTION OF THE HETEROZYGOUS/HOMOZYGOUS NATURE OF THE GENE LOCI INVOLVED, AND TO C ...

    SBIR Phase II 1989 Department of Health and Human Services
  4. AUTOMATED BEHAVIORAL HEARING TESTING DEVICE FOR INFANTS

    SBC: Artificial Hearing Systems Cp            Topic: N/A

    CONCERN ABOUT THE EFFECTS OF HEARING IMPAIRMENT ON A CHILD'S DEVELOPMENT IS CAUSING HEARING EVALUATION TO BECOME A ROUTINE PART OF PEDIATRIC CARE. WHILE THE COMMERCIAL MARKET HAS FOCUSED ON THE IMPROVEMENT OF ELECTROPHYSIOLOGIC PROCEDURES AND EQUIPMENT, BEHAVIORAL PROCEDURES WHICH MAY BE MORE APPROPRIATELY USED WITH OLDER INFANTS AND CHILDREN HAVE BEEN LARGELY IGNORED. THE OVERALL GOAL OF THIS PRO ...

    SBIR Phase II 1989 Department of Health and Human Services
  5. MAMMALIAN DNA SEQUENCE MAPPING CENTER

    SBC: Genetics Data Services Inc.            Topic: N/A

    BECAUSE OF THE RAPIDLY INCREASING USE OF IN SITU DNA SEQUENCE MAPPING TO MITOTIC CHROMOSOMES, A CENTER SHOULD BE ESTABLISHED TO DEVELOP THE MOST EFFICIENT TECHNIQUES AND TO AUTOMATE THE PROCEDURE. SUCH A CENTER WOULD MAKE AVAILABLE TO LABORATORIES INVOLVED IN THE CLONING OF DNA SEQUENCES THEABILITY TO EFFICIENTLY MAP TH SEQUENCES TO MAMMALIAN CHROMOSOMES. DNA SEQUENCING BY IN SITU HYBRIDIZATION WO ...

    SBIR Phase II 1989 Department of Health and Human Services
  6. PARENT-DIRECTED TREATMENT OF LEARNING DISABILITIES

    SBC: Lll Inc.            Topic: N/A

    LEARNING DISABILITIES, HYPERACTIVITY, AND OTHER DEVELOPMEN- TAL DISORDERS ARE STRESSFUL AND OFTEN PRODUCE SERIOUS EMOTIONAL DISTRESS AND BEHAVIOR PROBLEMS. LEARNING DIS- ABILITIES ALSO HAVE KNOWN NATURAL HISTORIES AND SPECIFIC REHABILITATIVE APPROACHES THAT ARE REMEDIAL AND THAT TEACH THROUGH COMPENSATORY AVENUES THAT HAVE BEEN USED FOR FIFTY YEARS, YET MANY PROBLEMS EXIST. LEARNING DISABILITY SER ...

    SBIR Phase II 1989 Department of Health and Human Services
  7. INVERSION OF LAPLACE TRANSFORMS ON MICROCOMPUTERS

    SBC: Micromath Inc.            Topic: N/A

    THE APPLICATION OF PHYSICAL-CHEMICAL PRINCIPLES TO BIOLOGICAL SYSTEMS FREQUENTLY LEADS TO SITUATIONS IN WHICH THE QUANTITATIVE TREATMENT OF CONCEPTUALLY SIMPLE MODELS IS CONFOUNDED BY THE COMPLEXITY OF THE SYSTEM. SUCH IS THE CASE, FOR EXAMPLE, IN THE STUDY OF THE PERMEATION (AND POSSIBLE CONCURRENT METABOLISM) OF DRUGS THROUGH COMPLEX BIOLOGICAL MEMBRANES, THE PHYSIOLOGICAL MODELING OF THE DISTRI ...

    SBIR Phase II 1989 Department of Health and Human Services
  8. CROSS-AXIS COIL PLANET CENTRIFUGE CHROMATOGRAPH DESIGN AND SYNTHESIS OF BRAIN-SPECIFIC ANTIHERPETIC AGENTS

    SBC: Pharmos Corporation            Topic: N/A

    A NEW COUNTERCURRENT CHROMATOGRAPHY INSTRUMENT, THE CROSS-AXIS FLOW-THROUGH COIL PLANET CENTRIFUGE IS PROPOSED FOR THE PREPARATIVE CHROMATOGRAPHY OF PEPTIDES. THIS IS AN APPARATUS THAT SEPARATES SUBSTANCES ACCORDING TO THEIR PARTITIONING IN A LIQUID-LIQUID EQUILIBRATION SYSTEM WITHOUTTHE USE OF A SOLID-PHASE SUPPORT. THE INSTRUMENT WILL BE TESTED IN THE PURIFICATION OF LARGE QUANTITIES OF SYNTHETI ...

    SBIR Phase II 1989 Department of Health and Human Services
  9. AN ULTRASONIC PLATELET HARVESTER

    SBC: Technical research Associates, Inc.            Topic: N/A

    TECHNICAL RESEARCH ASSOCIATES, INC. PROPOSES THE DEVELOPMENTOF A NOVEL PLATELET-HARVESTING SYSTEM BASED ON A PREVIOUSLY DEVELOPED ULTRASOUND SEPARATION TECHNOLOGY. THIS TECHNOLOGY, DEVELOPED UNDER AN NHLBI GRANT, ALLOWS THE SEQUENTIAL SEPARATION OF CELLS BASED ON THEIR SIZE, EVEN THOSE CELLS THAT HAVE IDENTICAL DENSITIES. FIRST, RESIDUAL ERYTHROCYTES AND LARGE LEUKOCYTES CAN BE SEPARATED FROM PLAT ...

    SBIR Phase II 1989 Department of Health and Human Services
  10. DIAGNOSTIC IMAGING INSTRUMENT DEVELOPMENT

    SBC: TECHNISCAN, INC.            Topic: N/A

    THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A PROTOTYPE SCANNING SYSTEM FROM WHICH NOVEL AND ADVANCED ULTRASOUND SCANNING SYSTEMS CAN BE MANUFACTURED FOR THE IMAGING, TISSUE CHARACTERIZATION, AND DIAGNOSIS OF CANCER AND OTHER DISEASES. IT WILL GIVE SUPERIOR IMAGES OF OBSTETRICAL CONDITIONS, VASCULAR DISEASE, LIVER DISEASE, ANDOTHER ABDOMINAL CONDITIONS. THIS ADVANCED SYSTEM IS BASED ON E ...

    SBIR Phase II 1989 Department of Health and Human Services

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