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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. INVERSION OF LAPLACE TRANSFORMS ON MICROCOMPUTERS

    SBC: Micromath Inc.            Topic: N/A

    THE APPLICATION OF PHYSICAL-CHEMICAL PRINCIPLES TO BIOLOGICAL SYSTEMS FREQUENTLY LEADS TO SITUATIONS IN WHICH THE QUANTITATIVE TREATMENT OF CONCEPTUALLY SIMPLE MODELS IS CONFOUNDED BY THE COMPLEXITY OF THE SYSTEM. SUCH IS THE CASE, FOR EXAMPLE, IN THE STUDY OF THE PERMEATION (AND POSSIBLE CONCURRENT METABOLISM) OF DRUGS THROUGH COMPLEX BIOLOGICAL MEMBRANES, THE PHYSIOLOGICAL MODELING OF THE DISTRI ...

    SBIR Phase II 1989 Department of Health and Human Services
  2. COMPUTER SOFTWARE FOR HYPERTHERMIA TREATMENTS

    SBC: CREARE LLC            Topic: N/A

    STRONG EVIDENCE EXISTS THAT ELEVATED TEMPERATURES, IN THE RANGE OF 42 TO 45 DEGREES(C) (HYPERTHERMIA), ARE AN IMPORTANT FACTOR IN THE DESTRUCTION OF CANCER CELLS, ESPECIALLY WHEN COMBINED WITH RADIATION THERAPY AND CHEMOTHERAPY. PRODUCING A CONTROLLED-TEMPERATURE DISTRIBUTION OF A GIVEN MAGNITUDE IS CRITICAL TO THE SUCCESS OF HYPERTHERMIA TREATMENT. RECENT ADVANCES IN COMPUTER TECHNOLOGY HAVE MADE ...

    SBIR Phase II 1989 Department of Health and Human Services
  3. AN ULTRASONIC PLATELET HARVESTER

    SBC: Technical research Associates, Inc.            Topic: N/A

    TECHNICAL RESEARCH ASSOCIATES, INC. PROPOSES THE DEVELOPMENTOF A NOVEL PLATELET-HARVESTING SYSTEM BASED ON A PREVIOUSLY DEVELOPED ULTRASOUND SEPARATION TECHNOLOGY. THIS TECHNOLOGY, DEVELOPED UNDER AN NHLBI GRANT, ALLOWS THE SEQUENTIAL SEPARATION OF CELLS BASED ON THEIR SIZE, EVEN THOSE CELLS THAT HAVE IDENTICAL DENSITIES. FIRST, RESIDUAL ERYTHROCYTES AND LARGE LEUKOCYTES CAN BE SEPARATED FROM PLAT ...

    SBIR Phase II 1989 Department of Health and Human Services
  4. DIAGNOSTIC IMAGING INSTRUMENT DEVELOPMENT

    SBC: TECHNISCAN, INC.            Topic: N/A

    THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A PROTOTYPE SCANNING SYSTEM FROM WHICH NOVEL AND ADVANCED ULTRASOUND SCANNING SYSTEMS CAN BE MANUFACTURED FOR THE IMAGING, TISSUE CHARACTERIZATION, AND DIAGNOSIS OF CANCER AND OTHER DISEASES. IT WILL GIVE SUPERIOR IMAGES OF OBSTETRICAL CONDITIONS, VASCULAR DISEASE, LIVER DISEASE, ANDOTHER ABDOMINAL CONDITIONS. THIS ADVANCED SYSTEM IS BASED ON E ...

    SBIR Phase II 1989 Department of Health and Human Services
  5. COMPUTER-DRIVEN PHASE-DIFFERENCE CRT HAPLOSCOPE

    SBC: Vision Research Corporation            Topic: N/A

    WE PROPOSE TO BUILD A COMPUTER-GRAPHICS, PHASE-DIFFERENCE, CRT HAPLOSCOPE. THIS WILL BE A PROGRAMMABLE, FLEXIBLE, STEREOSCOPIC DISPLAY SYSTEM USEFUL FOR: 1. RESEARCH IN BINOCULAR VISION, STRABISMUS, AND AMBLYOPIA; 2. CLINICAL SCREENING AND MEASUREMENT OF STRABISMUS AND AMBLYOPIA; AND 3. CLINICAL ORTHOPTICS. THE SYSTEM IS BUILT PRIMARILY FROM 'OFF-THE-SHELF' COMPONENTS TO REDUCE THE COST. LIQUID-CR ...

    SBIR Phase II 1989 Department of Health and Human Services
  6. HEAVY METAL REMOVAL AT THE PPB LEVEL FROM CULINARY WATER USING A NOVEL MACROCYCLE-SILICA GEL DEVICE

    SBC: IBC ADVANCED TECHNOLOGIES, INC            Topic: N/A

    IT IS DESIRABLE TO HAVE A MTHOD FOR EFFICIENT, COST EFFEC- TIVE, AND SIMULTANEOUS REMOVAL OF PB(II), AG(I), CD(II) AND HG(II) FROM POTABLE WATER TO LEVELS WELL BELOW THEIR EPA LIMITS. SUCH A METHOD COULD BE USED BY BOTH MUNICIPAL WATER WASTE TREATMENT PLALNTS. THE INTERACTION OF THE MACROCYCLE TETRAAZA-18CROWN WITH THE METALS OF INTEREST IS OF SUFFI- CIENT STRENGTH AND SELECTIVITY TO REMOVE THE ME ...

    SBIR Phase II 1989 Environmental Protection Agency
  7. A LONG-LIFE CENTRIFUGAL PUMP FOR HELIUM II TRANSFER

    SBC: CREARE LLC            Topic: N/A

    NASA CURRENTLY HAS SEVERAL ASTROPHYSICS MISSIONS PLANNED IN WHICH HELIUM REPLENISHMENT IS IMPORTANT. ONE OF THE TWO LEADING CANDIDATE REPLENISHMENT SYSTEMS REQUIRES A MECHANICAL PUMP. THIS PROGRAM IS INTENDED TO DEVELOP A LONG-LIFE CENTRIFUGAL PUMP TO MEET THESE REQUIREMENTS. IN PHASE I, A PRELIMINARY DESIGN AND ANALYSIS OF A SMALL HIGH SPEED CENTRIFUGAL PUMP WILL BE PERFORMED. THE PUMP WILL BE DE ...

    SBIR Phase II 1989 National Aeronautics and Space Administration
  8. MULTIGRID SOLUTION OF INTERNAL FLOWS USING GENERALIZED SOLUTION ADAPTIVE MESHES

    SBC: CREARE LLC            Topic: N/A

    IN THIS PROJECT, WE PROPOSE TO DEVELOP A MULTIGRID SOLVER FOR INTERNAL FLOWS USING GENERALIZED SOLUTION ADAPTIVE MESHES COMPOSED OF TRIANGULAR OR TETRAHEDRAL MESH CELLS. THE RESULTING COMPUTER PROGRAM WILL PERMIT THE SOLUTION OF THREE-DIMENSIONAL TRANSONIC VISCOUS FLOWS IN STATIONARY AND ROTATING DOMAINS, AND WILL HAVE THE ABILITY TO ACCURATELY REPRESENT GEOMETRICALLY COMPLEX CONFIGURATIONS AND TO ...

    SBIR Phase II 1989 National Aeronautics and Space Administration
  9. THREE PHASE INVERTER FOR ULTRA HIGH SPEED MOTOR DRIVE

    SBC: CREARE LLC            Topic: N/A

    SEVERAL OF THE LONG-LIFETIME CRYOCOOLERS BEING DEVELOPED FOR SPACE SENSOR APPLICATIONS ARE BASED ON THE REVERSE-BRAYTON CYCLE. AN ATTRACTIVE IMPLEMENTATION OF THE CYCLE WOULD USE HIGH-SPEED, MINIATURE CENTRIFUGAL COMPRESSORS AND TURBOEXPANDERS RUNNING ON GAS BEARINGS TO PROVIDE RELIABLE AND VIBRATION-FREE OPERATION. HARDWARE DEVELOPMENT AND DEMONSTRATION PROGRAMS ARE PRESENTLY UNDERWAY FOR THREE O ...

    SBIR Phase II 1989 National Aeronautics and Space Administration
  10. COMPACT HIGH PERFORMANCE HEAT EXCHANGERS FOR SPACE STATION THERMAL CONTROL

    SBC: CREARE LLC            Topic: N/A

    THIS PROPOSAL DESCRIBES A NOVEL CONCEPT FOR A SINGLE-PHASE HEAT EXCHANGER WHICH ATTAINS VERY HIGH HEAT TRANSFER RATES WITH VERY LOW PRESSURE LOSSES. THE NEW HEAT EXCHANGER OFFERS POTENTIAL BENEFITS TO THE SPACE STATION THERMAL CONTROL SYSTEM, PARTICULARLY THE LIVING MODULE TO THERMAL BUS HEAT TRANSPORT LOOP WHICH IS CONSTRAINED TO USE SINGLE-PHASE WATER AS THE THERMAL TRANSPORT FLUID. SUCH A SYSTE ...

    SBIR Phase II 1989 National Aeronautics and Space Administration

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