Award Data

DESCRIPTION (provided by applicant): Digoxin is the first line pharmacologic therapy for CHF and AF. Digoxin increases cardiac contractility and blocks conduction through the AV node slowing the ventricular response to AF and thus slowing the rate of the beating ventricles permitting more time for the heart to fill. The recent Dig trial supports the use of digoxin in the treatment of CHF and the r ...

Emissions of volatile organic compounds (VOCs) and hazardous air polutants (HAPS are a serioud environmental issue. These pollutants are requlated to protect human health and encourage the development of better control technologies. Current technologies to control thses emissions, until better materials are developed, include destructive and/or recovery-based technologies. Implementation of ads ...

This Small Business Innovation Research (SBIR) Phase II project will develop a new class of mechanical shaft seals based on the benefits of a novel material called Ultrananocrystalline (tm) diamond (UNCDtm) that will result in seals that last longer, save energy and reduce environmental emissions associated with industrial pumping and turbo-machinery applications. Mechanical shaft seals are used i ...

DESCRIPTION (provided by applicant): Stroke is the third leading cause of death in the United States and is the number one cause of adult disability. It is estimated that this clinical condition results in a cost of $30-40 billion in the U.S alone. While a large number of therapeutic agents have been investigated for the treatment of ischemic stroke, only one agent is currently approved for marke ...

The proposed effort is concerned with the development of a novel optimization scheme and computer software for the effective design of advanced aerospace vehicles. Since such vehicles are characterized by unprecedented levels of areo-structural-controls-propulsion interactions, a multidisciplinary simulation is essential for their effective design. This can be accomplished by employing the common ...

DESCRIPTION (provided by applicant): Current interbody fusion devices for lumbar fusion need improvement owing to lower than desireable success in fusion and difficulty in postoperative assessment effusion. A promising and novel approach for intervertebral fusion is to provide a cortico-cancellous structure that can withstand spine load adequately and provide a bioactive bony ingrowth surface to e ...

This Phase I proposal seeks to develop and demonstrate an improved first responder molecular analysis system based on a simplified methodology using aluminum oxide membrane (AOM) integrated sample preparation, amplification, and detection technology. This method has been shown to be faster, simpler, less expensive and more sensitive than existing methods. This proposal seeks to extend the applicab ...

This innovative SBIR Phase II proposal will develop next generation products for Thermal Control Material Systems (TCMS) an adhesives based on the next generation nano-cluster chemistry based new binder systems, through the systematic investigations to tailor required unique performance properties with reliability and durability. The efforts address a critical need of NASA which plans to undertak ...

The purpose of this STTR phase I proposal is to demonstrate the feasibility of producing the survivable multi-functional engineered material systems for spacecraft surfaces at an affordable cost using the proposed novel material designs and processes. The objectives of these efforts are not only to demonstrate the technical feasibility, but also to illustrate that at least 50% cost savings for DOD ...

DESCRIPTION (provided by applicant): Applied Medical Visualizations has developed a real-time graphical display showing model-based predictions of drug pharmacology (pharmacokinetics and pharmacodynamics), intended for use by anesthesiologists in the operating room. The administration of intravenous drugs improves when anesthesiologists are able to visualize model-predicted concentrations, effe ...