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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Project PREPARE: Preparing preschoolers and kindergartners who are deaf to learn to read by teaching them early critical service words typically visually and linguistically inaccessible to them through a computer-based instruction product

    SBC: HOPE, Inc.            Topic: N/A

    Children with significant hearing loss continually exhibit low reading levels, due in part to the difficulty they face upon entering school of understanding basal reading vocabulary, especially critical service words. Service words cannot easily be learned through the use of pictures or objects but constitute up to 75% of all words used in basal readers, including prepositions, conjunctions, artic ...

    SBIR Phase II 2005 Department of Education
  2. COMMERCIALIZATION OF GRAPHICAL INTRAVENOUS DRUG DISPLAY

    SBC: APPLIED MEDICAL VISUALIZATIONS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Applied Medical Visualizations has developed a real-time graphical display showing model-based predictions of drug pharmacology (pharmacokinetics and pharmacodynamics), intended for use by anesthesiologists in the operating room. The administration of intravenous drugs improves when anesthesiologists are able to visualize model-predicted concentrations, effe ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. REBREATHING ABSORBER TO SPEED EMERGENCE FROM ANESTHESIA

    SBC: Axon Medical Inc            Topic: N/A

    DESCRIPTION (provided by applicant): When general anesthesia is administered, anesthetics in the form of vapors are delivered to a patient in 1% to 5% concentrations. Once the surgical procedure has been completed and anesthesia is no longer administered, blood carries the inhaled anesthetic from the brain to the lungs where it is exhaled from the body. The higher the brain blood flow and the ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. High Throughput DSC for Drug Screening

    SBC: Energetic Genomics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): High-throughput screening approaches are ubiquitious in the pharmaceutical industry as part of the drug discovery process. A variety of sensors are used in these screens, the most common of which are spectroscopic. Such absorbance or fluorescence based high-throughput screens inevitably require the use of extrinsic probes to provide a signal, and often require ...

    SBIR Phase II 2005 Department of Health and Human Services
  5. Inhibition of Intestinal Heme Iron Absorption

    SBC: Frontier Scientific Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Iron overload syndromes (attributable to transfusions / dietary uptake) are a significant cause of the morbidity and mortality associated with hemochromatosis, thalasemia, and sickle cell anemia. In the developed world, 2/3 of absorbed iron is derived from heme (organic iron) rather than inorganic iron. While the mechanism by which inorganic iron is absorbed i ...

    SBIR Phase II 2005 Department of Health and Human Services
  6. Homogeneous Mutation Scanning

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Our objective is to provide a homogeneous, closed-tube system for DNA mutation scanning on a high-throughput platform. For many complex genetic diseases, it is very difficult and expensive to screen for all possible mutations that may cause the disease. We propose a relatively simple solution. Certain dyes are compatible with PCR and can detect sequence alterat ...

    STTR Phase II 2005 Department of Health and Human Services
  7. FilmArray-A Closed System for Multi-Pathogen Screening

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Polymerase chain reaction (PCR) has become the method of choice for rapid diagnosis of infectious agents. To identify an infectious agent by molecular means requires a panel of PCR assays. So called "multiplex PCR" concurrently assays for multiple targets in a single reaction. Multiplex PCR has proved valuable in some systems, but shortcomings exist concerning ...

    SBIR Phase I 2005 Department of Health and Human Services
  8. A System for Rapid PCR, Mutation Scanning and Genotyping

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Our objective is to provide a closed-tube system for rapid PCR, mutation scanning and genotyping that does not require fluorescently-labeled probes. For many genetic diseases, it is difficult and expensive to screen for all possible mutations that may cause the disease. We propose a relatively simple solution for rapid amplification, scanning and genotyping in ...

    STTR Phase I 2005 Department of Health and Human Services
  9. A System for Rapid PCR, Mutation Scanning and Genotyping

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Our objective is to provide a closed-tube system for rapid PCR, mutation scanning and genotyping that does not require fluorescently-labeled probes. For many genetic diseases, it is difficult and expensive to screen for all possible mutations that may cause the disease. We propose a relatively simple solution for rapid amplification, scanning and genotyping in ...

    STTR Phase II 2005 Department of Health and Human Services
  10. Genotype Analysis for Diagnosis of Urea Cycle Disorders

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Urea Cycle Disorders (UCDs) are metabolic diseases disrupting ureagenesis. Unequivocal and rapid diagnosis of UCDs is difficult because hyperammonemia, the primary biochemical phenotype, is not specific to UCDs being observed in broad categories of metabolic deficiencies including fatty acid oxidation defects, lactic acidosis, and organic acidemias. Clinical p ...

    SBIR Phase I 2005 Department of Health and Human Services
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