Award Data

DESCRIPTION provided by applicant In the proposed study a novel approach which has already generated multiple commercial sales for SilcsBio LLC Site Identification by Ligand Competitive Saturation SILCS will be further developed to address customer requests and concerns around SILCS utility Successful commercial application of computational methods for ligand design require a platform th ...

DESCRIPTION provided by applicant The Specific Aim of this proposal is to test the feasibility of developing a catheter based indwelling biosensor for the real time continuous monitoring of chemotherapeutic blood levels of lung cancer patients A tool that continuously monitors blood drug levels in real time will enable an unprecedented understanding of an individual patientandapos s distinct ...

Deaf and hard-of-hearing students may lag behind their hearing peers in English literacy and in science, technology, engineering, and mathematics (STEM). Evaluations in classroom and informal environments have demonstrated the efficacy of the dictionaries in increasing student engagement and mastery of math and science content and vocabulary. This project develops a cloud-based service and corresp ...

This project develops and refines new fabrication methods to drastically reduce the cost and complexity of universally accessible interactive maps and models for wayfinding and orientation in public places. During Phase I, researchers design, implement, and evaluate the Talking Campus Model for Overbrook School of the Blind. The model includes opaque scale models of campus buildings placed on a tr ...

DESCRIPTION provided by applicant Recent studies by my laboratory and collaborators and by others have demonstrated that RNA trans splicing can correct mutations in many different genes in a wide range of disease model systems including Huntingtonandapos s disease Trans splicing is one of a handful of techniques that can convert the expression of a dominant negative mutation into the normal p ...

DESCRIPTION provided by applicant Smoking remains the number one avoidable cause of death in the United States and costs the economy tens of billions of dollars every year Current therapies include nicotine replacement with a patch or gum inhibition of the dopamine system with bupropion and partial activation of the neuronal nicotinic acetylcholine receptor nAChR with varenicline Non ...

DESCRIPTION provided by applicant Non Hodgkin lymphoma NHL is the most commonly diagnosed hematologic malignancy in the U S with over new cases and about deaths due to NHL expected in Over one third of all cases are slow growing or indolent NHL iNHL which affect older adults and typically present as advanced disease The initial treatment of iNHL consists of an anti CD ...

DESCRIPTION provided by applicant Diabetic retinopathy DR is a common complication of diabetes and a leading cause of vision loss in the United States Although the anti vascular endothelial growth factor VEGF drugs have shown impressive efficacies on wet age related macular degeneration AMD they are only effective in approximately of patients with DR likely due to the multi factori ...

DESCRIPTION provided by applicant In the United States nearly of all pregnant women are prescribed one or more drugs during pregnancy The impact on public health is significant Approximately birth defects are due to drugs taken during pregnancy Additionally many patients fear that exposure to any medication during pregnancy will cause harm to the embryo fetus and this fear has ...

DESCRIPTION provided by applicant Technology to deliver molecules andquot on demandandquot that bind to targets or catalyze reactions of a technologistandapos s choosing would have enormous commercial value in research manufacturing and medicine Thus this has been a andquot holy grailandquot of molecular science for a half century Even today chemical theory is inadequate to support de ...