Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Novel selective alpha4beta2 nicotinic receptor antagonists for smoking cessation

    SBC: ASSUAGE PHARMACEUTICALS, INC.            Topic: NIDA

    DESCRIPTION provided by applicant Smoking remains the number one avoidable cause of death in the United States and costs the economy tens of billions of dollars every year Current therapies include nicotine replacement with a patch or gum inhibition of the dopamine system with bupropion and partial activation of the neuronal nicotinic acetylcholine receptor nAChR with varenicline Non ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Receptors, Ligands, and Catalysts on Demand using Expanded Genetic Alphabets

    SBC: FIREBIRD BIOMOLECULAR SCIENCES LLC            Topic: 100

    DESCRIPTION provided by applicant Technology to deliver molecules andquot on demandandquot that bind to targets or catalyze reactions of a technologistandapos s choosing would have enormous commercial value in research manufacturing and medicine Thus this has been a andquot holy grailandquot of molecular science for a half century Even today chemical theory is inadequate to support de ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Development of DT-109 as an oral therapeutic for type 2 diabetes

    SBC: Diapin Therapeutics LLC            Topic: 200

    DESCRIPTION provided by applicant Type diabetes T D is chronic disease characterized by high blood glucose and rapidly emerged as a global health care problem that threatens to reach pandemic levels by Nearly million people worldwide are currently affected by diabetes Diabetes is a major cause of heart disease and stroke and also leads to other complications such as vision loss ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Kits for high-multiplexed detection of RNA viruses in complex biological samples

    SBC: FIREBIRD BIOMOLECULAR SCIENCES LLC            Topic: 300

    DESCRIPTION provided by applicant The public health challenges from RNA viruses are at a tipping point with dengue moving up Florida human transmission of chickungunya now established in Florida and transmitted by different mechanism Ebola While these have long been a challenge their incidence has been predominantly overseas In addition the health hazards of other RNA viruses better k ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Isolation and Characterization of Low Molecular Weight Compounds Derived from Plant Extracts that Activate the IRS-2 Dependent Insulin Signaling Cascade.

    SBC: HOUSEY PHARMACEUTICAL RESEARCH LAB            Topic: 200

    DESCRIPTION provided by applicant This is a Phase I SBIR Application entitled andquot Isolation and Characterization of Low Molecular Weight Compounds Derived from Plant Extracts that Activate the IRS Dependent Insulin Signaling Cascade andquot Diabetes is a growing and significant global health concern Insulin Receptor Substrate IRS is a critical component in the insulin mediated s ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Novel Inhibitors of Multi-Drug-Resistant Mutants of BCR-ABL for the Treatment of Chronic Myelogenous Leukemia (CML) and Ph Positive Acute Lymphocytic Leukemia (ALL).

    SBC: HOUSEY PHARMACEUTICAL RESEARCH LAB            Topic: 102

    DESCRIPTION provided by applicant This is a Phase I SBIR Application entitled andquot Novel Inhibitors of Multi Drug Resistant Mutants of BCR ABL for the Treatment of Chronic Myelogenous Leukemia CML and Ph Acute Lymphocytic Leukemia ALL andquot The overall goal of this proposal is to further optimize and improve the efficacy of novel classes of compounds discovered developed and patent ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Improving Outcomes for Mechanically Ventilated Patients with the Digital EZ Board

    SBC: VIDATAK, LLC            Topic: 600

    DESCRIPTION provided by applicant Effective communication between patients and healthcare professionals is essential to achieve positive clinical outcomes Patients who are unable to communicate effectively e g patients with limited English proficiency LEP those who are hearing impaired aphasic or have oral tracheal intubation experience extreme frustration panic anxiety sleeplessne ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Small blood pumps for small patients

    SBC: Vadovations, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Heart failure and congenital heart defects threaten the lives of several thousand children each year The only FDA approved long term pediatric heart support device is the Berlin Heart Excor which is based on year old technology and is fraught with complications including blood clots forming in the device requiring frequent device replacement The recipien ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Family Supportive Supervisor Training and Workplace Assessment Tool

    SBC: WORK LIFE HELP, INC.            Topic: NIA

    DESCRIPTION provided by applicant Managing the demands of work and personal life is a major stressor affecting employees yet there are virtually no evidence based workplace supervisory training interventions to address this critical public health concern Research has shown work family conflict can affect employeesandapos health workplace productivity family interactions and safety and wel ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Early diagnosis of acute kidney injury by aptasensors

    SBC: Aptalogic, Inc.            Topic: 400

    DESCRIPTION provided by applicant Acute kidney injury AKI affects more than million people worldwide each year with reported mortalities from to in different patient populations However methods are lacking to support the early diagnosis of AKI that could lead to early intervention improved therapy better prognosis and lower medical costs For these reasons the development of e ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
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