Award Data

Our biosensor is made of silicon nanowire arrays functionalized with antibodies to measure the concentration of specific proteins. In this grant we will take a sensor that has been demonstrated for use in measuring a set of generic host cell proteins and we will apply the sensor to measure a set of proteins for a specific cell line. In doing so, we will demonstrate the utility of our sensor to be ...

Phase I has proven that the current setup achieves better than 8mm spatial resolution for 2.2MeV prompt gammas. However, 1mm spatial resolution presents a significant challenge for the current setup due in part to limited timing resolution and count rate. A new analog ASIC will be developed to replace the current analog ASIC that will have better timing resolution and deliver higher count rates. I ...

Industrial facilities, manufacturing plants, and electric power plants that burn fossil fuels exhaust the combustion products to atmosphere through their smokestacks. Stack pollutant emissions are quantified using manual testing methods developed in the 1960s, which are prone to error if non-axial flow exists in a stack.Recently, NIST has been working on an improved technique of performing 3D flow ...

To evaluate the technical feasibility of prompt gamma neutron activation (PGAA) as an alternative to a set of standard destructive tests of concrete petrography including aggregate type, water/cement ratio, aggregate/binder ratio, density, chloride content and chloride bulk diffusion constant; and to determine the specifications for the design of a dedicated commercial laboratory-based PGAA facili ...

Categorical theory has recently been successfully applied to translate information from one computer system to another. Researchers at MIT have developed a prototype software tool based on category theory for solving information-integration programs. The tool has successfully solved small-scale information-integration problems including a problem identified by NIST about enriching the manufacturin ...

methyst Research Inc. will design, fabricate and test a high uniformity, large area, low noise infrared trap-detector detector for the 1- 4.5 μm wavelength range. This state of the art detector will have a large area (e.g., 1-1.8 cm diameter active area) with a spatial variability of internal quantum efficiency of less than 0.1 % between 1 μm and 4.5 μm. In addition, the internal quantum effici ...

This Phase II project will continue the prototype development of a pharmaceutical spray quality audit system. The spray quality audit system will estimate the planar mass distribution, mass flux, and drop size of pharmaceutical sprays that are used in functional coating applications and inhalers. A prototype tomography system will be designed and fabricated and evaluated using various fluorophore.

To further advance the characterization and utility of microcantilevers, next generation optical detectors with higher frequency response, improved displacement resolution and lower noise for weak signal detection are needed. Consequently, Radiation Monitoring Devices, Inc. (RMD) will develop a turnkey optical detector module for use in characterizing the displacement and resonant frequencies of m ...

In Phase 1, TIAX developed and demonstrated a residential energy monitoring system (R-EMS) with potential national energy savings of $20 billion annually. Based on user requirements and well-established systems engineering methodology, TIAX’s R-EMS solution is inexpensive, easy to install and operate, and is supportive of intuitive decision making about energy usage. In Phase 2, TIAX will extend ...

The objective of this proposal is to establish the feasibility of developing an integrated decision support tool that transforms the current time-consuming and reactive (post-design) sustainability assessment into a real-time, proactive approach available in the early phases of product design. This tool, called Sustainability Integrated into Early Design (SIED), will define and capture lifecycle-w ...