Award Data

Project Summary Abstract Synthetic arteriovenous grafts AVGs can provide life sustaining vascular access for dialysis patients but are subject to multiple modes of failure and complications related to chronic needle cannulation poor graft identification delayed access and bleeding These graft needle cannulation associated complications translate to millions of dollars in health care expense ...

Project Summary Nucleosomes are the fundamental and repeating units of chromatin consisting of DNA wrapped around a histone octamer Alterations in chromatin structure and function dramatically impact downstream gene expression and cellular physiology This epigenetic regulation is controlled by two major modifications histone post translational modifications PTMs such as histone methylation ...

THE TOPIC OF THIS PROPOSAL IS THE DESIGN OF AN ENVIRONMENTALCONTROL SYSTEM FOR THE MORE THAN TWO MILLION INDIVIDUALS IN THE UNITED STATES WHOSE PHYSICAL AND/OR MENTAL IMPAIRMENTS ARE SO SEVERE THAT THEY ARE UNABLE TO FUNCTION IN THEIR ENVIRONMENT IN A NORMAL AND EFFECTIVE MANNER. A TWO-YEAR COLLABORATIVE RESEARCH EFFORT BETWEEN THE BIOENGINEERING PROGRAM AT THE NATIONAL HEADQUARTERS OF THE ASSOCIA ...

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For this Phase I SBIR proposal, Vcom3D proposes to design an Advanced Female Trauma Training System that features the accurate representation of anatomical and physiological differences of the women in our nations armed forces, and of the types of injuries that they are most likely to sustain in combat. The training system will include a ruggedized medical manikin and a wireless tablet controller ...

THE CONTRACTOR SHALL DEVELOP A FUZZY SET METHODOLOGY FOR UNCERTAINTY ANALYSIS IN PROBABILISTIC SEISMIC SAFETY ASSESSMENT OF NUCLEAR POWER PLANTS. FUZZY SET LOGIC WILL BEUSED FOR COLLECTING, QUANTIFYING AND PROPAGATING SUBJECTIVE,ENGINEERING JUDGEMENT USED IN THE UNCERTAINTY ANALYSIS. IN PHASE I, FEASIBILITY OF THE PROPOSED APPROACH WILL BE DEMONSTRATED BY APPLYING IT TO SELECTED PARTS OF A PROBABI ...

DESCRIPTION provided by applicant The Specific Aim of this proposal is to test the feasibility of using vagus nerve stimulation VNS as an adjunct to prolonged exposure therapy PE for treating PTSD patients who are refractory to PE PE is the treatment of choice for such patients However PE is successful in as few as of cases Refractory PTSD patients have high rates of suicide substa ...

DESCRIPTION provided by applicant Each year million US children are injured affecting the child his her family and society which often bears the cost Among school age children age to injuries lead to million emergency department ED visits and hospital admissions annually resulting in $ billion in medical costs and $ billion more in work loss costs Approxima ...

METRACO, INC. PROPOSES TO DEVELOP A PROTOTYPE EVOKED-POTENTIAL INSTRUMENT THAT WILL ALLOW AUTOMATED SCREENING FOR HEARING PROBLEMS IN THE NEWBORN INFANT. THE INSTRUMENT WILL PROVIDE NEW, UNIQUE FEATURES AND TECHNOLOGY UNAVAILABLE IN EXISTING INSTRUMENTS. THE MAJOR GOALS ARE: (1) TO IMPROVE THE EFFECTIVE SIGNAL-TO-NOISE RATIO AND ERROR REDUCTION ABILITY BY COMPUTATION OF THE MEDIAN RATHER THAN THE ...

DESCRIPTION provided by applicant The goal of this SBIR project is to develop a method for creating algorithmically generated control groups These will be composed of synthetic cases that have two characteristics pretest similarity to whatever prevention treatment group may present itself and patterns of change over time that closely mimic the normal course of alcohol and drug use d ...