Award Data

PROJECT SUMMARYNucleosomesNucsare the repeating units of chromatinmade up of DNA wrapped around a histone octamerChanges in chromatin structurefunction can dramatically impact downstream gene expression and cellular physiologydriving oncogenic reprogramming and cancer progressionThis epigenetic regulation of chromatin is controlled by two major modificationshistone post translational modifications ...

PROJECT SUMMARY The proposed Phase I STTR project is a partnership between a biotechnology company KXTbioIncand the University of North Carolina at Chapel Hill to develop an innovative high throughput screening service for identifying new drug candidates that act via G protein coupled receptorsGPCRsThis large protein superfamily has been the most successful source of therapeutic targetsaccounting ...

PROJECT SUMMARY We propose to build a cloud based integrated solution for scalablecustomizableprivacy preservingand interactive antibody repertoire analysisImmune repertoire sequencingIR seqhas become a useful tool in both basic research and clinical settingsAs the heart of the adaptive immunity to infection and many vaccinesthe abundance and diversity composition of the B cell receptorBCRand its ...

ABSTRACT A Comprehensive Newborn Screening Solution for Duchenne and Congenital Muscular DystrophiesFast Track SBIRCongenital genetic abnormalities are a leading cause of childhood mortality and morbidityWhile routine newborn screeningNBShas dramatically improved health outcomesmany congenital disorders such as Duchenne muscular dystrophyDMDand other congenital muscular dystrophiesCMDare not curre ...

Abstract Autism Spectrum DisorderASDis a life long neurodevelopmental disorder characterized by social communication deficits and repetitive behaviors and interestsWith overyouth with ASD entering adulthood in the next decadethere is an urgent need for the development of cost effectiveaccessibleand evidence based interventions to support the transition to competitive employmentLike their typically ...

Project Summary Abstract PTIis a novel small molecule AD therapeutic candidate with a novel target and mechanism of actionPTIbinds and reverses an altered conformation of the scaffolding protein filamin AFLNAto prevent Aandapos s tight binding to and toxic signaling via thenicotinic acetylcholine receptornAChRas well as Aandapos s aberrant activation of toll like receptorTLRHenceby restoring FLNAa ...

Parent Award: R44CA217587 Clinical Evaluation of the novel, Uni-directional Pd-103 CivaSheet for Lung Cancers CivaTech Oncology’s mission is to provide improved radiation therapy directly to localized tumors. The Company has developed a novel, polymer-encapsulated, membrane-like radiation source that emits radiation on only one side of the device – CivaSheet®. This directional source is compa ...

Project Summary Abstract Confusionbeing lostand losing track of oneandapos s orientation within large or unfamiliar indoor spacesthese are some of the biggest challenges facing people with visual disabilitiesSince GPS typically doesnandapos t work indoorsand isnandapos t fine grained enough anywayindividuals who cannot readily access visual information are at a significant disadvantageand many bli ...

THE CONTRACTOR SHALL DEVELOP A FUZZY SET METHODOLOGY FOR UNCERTAINTY ANALYSIS IN PROBABILISTIC SEISMIC SAFETY ASSESSMENT OF NUCLEAR POWER PLANTS. FUZZY SET LOGIC WILL BEUSED FOR COLLECTING, QUANTIFYING AND PROPAGATING SUBJECTIVE,ENGINEERING JUDGEMENT USED IN THE UNCERTAINTY ANALYSIS. IN PHASE I, FEASIBILITY OF THE PROPOSED APPROACH WILL BE DEMONSTRATED BY APPLYING IT TO SELECTED PARTS OF A PROBABI ...

Abstract Critical to the future progress of cancer immunotherapies is the discovery and tracking of T cells specific for cancer cells but not normal tissuesNeo antigen derived from mutations are a group of attractive antigens for cancer immunotherapyBecause they are mutated variants of self antigensthey are immunologically considered as foreign antigens and are not part of the self antigensThusthe ...