Award Data

THERE IS A CLEAR NEED FOR AN EMERGENCY OXYGEN DELIVERY SYSTEM THAT COMBINES RELIABILITY, LONG-TERM STORAGE CAPABILITY, VARIABLE AND CONTROLLABLE FLOW RATE, SMALL SIZE,SAFETY, AND SIMPLICITY OF USE. OF THE AVAILABLE OXYGEN STORAGE MEDIA, CHEMICAL SYSTEMS OFFER A REASONABLE LIKELI- HOOD OF ACHIEVING SUCH A SYSTEM. THIS PROJECT WILL INVESTIGATE THE FEASIBILITY OF USING LOW-COST HYDROGEN PEROXIDE AS T ...

THE SPECIFIC GOAL OF THIS RESEARCH IS THE DEVELOPMENT OF A PORTABLE OXYGEN SOURCE SUITABLE FOR USE IN PROVIDING SUPPLE-MENTAL OXYGEN TO INDIVIDUALS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) RESULTING FROM CHRONIC BRONCHIOLI- TIS, PULMONARY EMPHYSEMA, ASTHMA, OR CHRONIC BRONCHITIS. THE CONCEPT IS BASED ON THE USE OF A COMMON, LOW-COST, HOUSEHOLD CHEMICAL THAT GENERATES OXYGEN WHEN WATER PLU ...

THE SPECIFIC AIM OF THIS STUDY IS TO DESIGN AND EVALUATE THEUSE OF HEPA-FILTERED, LAMINAR FLOW ISOLATION SYSTEMS AS SUBSTITUTES FOR PRESENT BARRIER SYSTEMS IN GERM-FREE AND GNOTOBIOTIC RESEARCH USING RODENTS AND OTHER SMALL ANIMALS.

DESCRIPTION (provided by applicant): C. perfringens epsilon-toxin (ETX) is a potential biological weapon included in the list of category B priority agents. The overall goal of this proposal is to identify and perform in vivo testing of new inhibitors of E TX using a novel approach for the inactivation of pore-forming toxins developed at Innovative Biologics, Inc. It is based on the blocking of th ...

THE URINARY TRACT IS A MAJOR SITE OF NOSOCOMIAL INFECTIONS. THE LEADING CAUSE OF THESE INFECTIONS IS URINARY CATHETERIZATION, WHICH IN TURN IS THE MOST COMMON PREDISPOSING FACTOR FOR FATAL GRAM-NEGATIVE SEPSIS IN HOSPITALS. THE LONG-TERM OBJECTIVE OF IONTOPHORETIC CATHETER RESEARCH IS TO DEVELOP A DEVICE TO PREVENT CATHETER-RELATED URINARY TRACT INFECTIONS. THE ULTIMATE CONFIGURATION ENVISIONED CO ...

DESCRIPTION (provided by investigator): Lyme disease, caused by the gram-negative spirochete Borrelia burgdorferi and transmitted by Ixodid tick species, is the leading vector-borne infectious disease in the United States, with a steady rise in the number of cases reported each year. The most common Lyme disease symptom, the classic bull's-eye rash (erythema migrans or EM rash) in endemic areas, ...

DESCRIPTION (provided by applicant): This project aims to develop talactoferrin (TLF, recombinant human lactoferrin) as a therapeutic agent to treat prematurely born neonates. The treatment will be given orally shortly after birth to prevent nosocomial inf ections (NIs) due to abnormal bacterial invasion of neonatal intestinal epithelia and consequently to limit systemic bacteremia and necrotizing ...

DESCRIPTION (provided by applicant): Severe sepsis is a major cause of morbidity and mortality throughout the world. It is the leading cause of death in non-coronary intensive care units (ICUs) in the United States, with more than 750,000 cases occurring every year. This means that in the United States, more than 500 patients die from severe sepsis every day, with 28% to 50% of the patients succum ...

DESCRIPTION (provided by applicant): The siRNA molecule needs better protection from nuclease degradation before it can be effectively used as a therapeutic. AM Biotechnologies (AM) will address this critical issue by developing ribonucleoside thiophospho ramidite (ABz, CBz, GIbu and U) reagents that will enable synthesis of phosphorodithioate siRNA (PS2-siRNA). This synthesized PS2-siRNA will si ...

DESCRIPTION (provided by applicant): Lymph node evaluation is an important prognostic factor in colorectal cancer (CRC) because accurate identification of lymph node metastases significantly influences survival. However, a 30% recurrence rate in patients w ith node-negative CRC clearly indicates that current staging methods are inadequate. The primary form of treatment for all stages of colon canc ...