Award Data

Luna Innovations proposes to develop for NIST a low-cost, yet high resolution acoustic sensor system capable of determining micro-degree changes in a water path caused by clinical medical radiation devices. The sensors are external to the water and play a negligible role in thermal transfer in contrast to current thermocouple devices in use today. An exciting element in this proposal is APPLES' ab ...

For this Phase I SBIR proposal, Vcom3D proposes to design advanced medical moulage that accurately simulates the progression of an injury or pathology by morphing through a series of clinical states to enable learners to confirm the progression of the wound and to determine whether iatrogenic errors or pathologies occurred duing treatment. The physical morphing moulage may be applied to medical m ...

HemoSonics LLC is developing an easy to use and easy to interpret diagnostic device to rapidly identify diffuse coagulopathies in order to guide proper and evidence-based interventions. The management of diffuse coagulopathies is extremely important in military medicine as these conditions represent a significant source of combat morbidity and mortality. HemoSonics device is based on sonorheometry ...

The EPA estimates that one out of every four Americans lives within three miles of a hazardous waste site. Recent advanced materials developments have driven increased use of In Situ Chemical Reduction (ISCR) remediation in the US and globally. Nanoscale Zero Valent Iron (NZVI) holds great potential for ISCR due to its low cost and high capacity for degrading halogenated compounds. However, two ma ...

Current strategies for the treatment of osteochondral injuries are ineffective and are associated with significant side effects. Microfracture techniques have demonstrated limited efficacy over long periods of time and are less effective for larger osteochondral defects. Osteochondral autograft transplants require harvesting from a donor site, which can lead to donor site morbidity. And while auto ...

Realistic surgical simulation requires a combination of representative tissue geometry, accurate tissue material properties and lifelike tool-tissue interaction forces. Recent advances in computational power and imaging modalities have provided the capability to represent the anatomical details required for surgical training; however, the mathematical models which govern the underlying tissue pro ...

Traumatic brain injury (TBI) impacts over two million Americans annually, and is the signature injury of the Iraq and Afghanistan conflicts. Therapeutic hypothermia is a promising neuroprotective technique for treating TBI, but reduced body temperature is a threat to soldiers in military operations with multiple injuries. Mainstream has proposed a novel heat pump cooling system that overcomes the ...

Our proposal develops an osteochondral repair platform that is conformable to a wide variety of injury geometries without the need for pre-operative customization. Further this platform does not rely on any autologous tissue and is amenable to scalable manufacturing methods. The basis of this platform is a targeted delivery technology that permits site-specific osteo-chondral induction within inj ...

Estimation of the primary parameters like IC 50 in traditional dose-response modelsmay fail or lead to misleading results when the observations are non-onotonic due to drugresistance or virus mutation in various biomedical lab research. The objective of this project isto develop a novel approach to assess dose response relationship, which is applicable to generalpharmacologic, toxicologic, or othe ...

A semiconductor metrology tool will be developed employing the technique of small-angle x-ray scattering (SAXS) to measure the critical dimension (CD) of patterned device structures. The feasibility of the SAXS technique to measure CD has been shown using high-power synchrotron radiation facilities which are not of practical use to the semiconductor industry. The ultimate project goal is to produc ...