Award Data

In this project, Parabon NanoLabs will employ its Essemblix(tm) Drug Development Platform, a combination of computer-aided design (CAD) software and DNA nano-fabrication technology, to produce artificial vaccines against the biothreat agent ricin on DNA origami decorated first with natural epitopes and ultimately with artificial epitotopes (hereafter"mimotope") constructed from a predefined set of ...

Existing clinical decision support systems (CDSS) for TBI/PTSD are not well integrated with clinical pathways, terminologies/codes, and/or electronic medical records. Further, these CDSS do not leverage the latest computing technologies such as cloud computing, speech recognition, mobile computing and NLP. In particular, latest advances in machine learning / predictive analytics are not utilized. ...

We propose to design and develop a Cohort Development and Analysis Toolkit (CDAT) that will assist clinicians, practice administrators and public health professionals in comparing the effectiveness of different clinical practices, including preventive and treatment modalities. The overall goal of CDAT is to facilitate comparative effectiveness research and evidence-based practice without the nece ...

nanoRETE is a developing a nanoparticle-based biosensor technology platform that has the ability for real-time detection of pathogens. Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis (Mtb) that primarily affects the lungs. In Phase I research, nanoRETE demonstrated proof-of-concept of an electrochemical nano-bead biosensor for measuring plasma cytokine and chemokine concentrati ...

Current therapies to prevent scar formation and contracture of burns are minimally effective. QuickMed Technologies (QMT) proposes to develop an advanced therapy to enhance healing and prevent contraction of burn scars by combining the advanced prototype BURN-PLUS dressing with Endoform dermal template. BURN-PLUS is an occlusive island dressing with an adhesive apron bonded onto a super absorben ...

The goal of the Environment, Epidemiology, and Etiology Surveillance and Analysis Toolkit (E3SAT) project is to develop a data analysis infrastructure, models and templates to facilitate environmental, epidemiological and etiological analysis. E3SAT provides a research data cube and analysis tool suite that allows researchers to collect, integrate and data mine medical information, environmental ...

Peripheral Neuropathy (PN) is a painful debilitating condition caused by progressive subcutaneous nerve damage due to diabetes, chemotherapy or as a result of traumatic combat injuries. Systemic or topical administration of existing therapeutics alleviates pain but does not address progressive nerve damage. High dosages requisite for therapeutic effect increase long-term toxicity risk. Lynntech ...

In our Phase II project Oceanit will further develop the proof of concept LCG and associated high thermal conductivity tubing into fully functional prototypes. These prototypes will be tested using a human model, thermal manikin (TM) and field testing by AFSOC personnel. Our approach provides a fundamental improvement, increasing human-machine coupling, with far reaching benefits in efficiency. Th ...

Flying insect vectors and the diseases they transmit continue to be a significant source of concern for United States service members deployed in field operations. In an effort to reduce contact between the vectors and humans, military entomologists are often required to perform surveillance to assess the prevalence of disease vectors and to evaluate the effectiveness of control measures. Survei ...

This Phase I project is relevant to the ultimate goals of this program announcement given the prevalence of the IED which often creates complex burn wounds on the face and skin that often form hypertrophic scars that often contract over time. Burn wound healing is a complex process that includes phases of inflammation, granulation tissue formation, re-epithelialization, and, finally, remodeling. ...