Award Data

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

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ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

THE BIOCHEMICAL AND SYNTHETIC CAPACITY OF HIGHER PLANTS, AS SHOWN BY THEIR NATURAL CONTENT OF SUBSTANCES, HAS BEEN USED FOR CENTURIES IN SUPPLYING MATERIALS IMPORTANT IN PHARMACOLOGY AND IN FLAVORS AND FRAGRANCES. MANY OF THESE SECONDARY PRODUCTS ARE IN SHORT SUPPLY AND AN ENORMOUS EFFORT HAS TO BE EXTENDED TO GET THEM. ATTEMPTS TO USE CELL CULTURES OF HIGHER PLANTS AS A MEANS OF PRODUCING SECONDA ...

DESCRIPTION provided by applicant Introduction The Blink based Communication BLINC System will allow any patient who retains oculomotor control to reliably signal for assistance and communicate basic requests to a caregiver It uses infrared IR cameras and illuminators to continuously monitor a patient in bed and to detect blink signals even in a dark room It is specifically designed so ...

The traditional view of arithmetic operations dominating the computational cost of numerical algorithms has changed. As performance of new processors increases, we are moving into a new reality in which data movement is expensive and operations are becoming nearly free. In Phase I we discovered a new theory of data compression with unprecedented capability to reduce data movement in distributed HP ...

There is growing interest in computerized systems to increase accessibility of assessments for students with disabilities. Technology offers an ideal platform for implementing Universal Design (UD) principles for assessment to better accommodate student diversity and support broad student participation. The goal of this Phase II SBIR project is to continue the research and development of Assess2Pr ...

Project Abstract Active surveillance (AS) is becoming more accepted as a reasonable treatment option for men with low-risk prostate cancer (i.e. Gleason score 6, clinical stage T2a, PSA lt 10). Many AS protocols at major institutions call for a prostate saturation biopsy after initial diagnosis to confirm that the patient has no areas of higher-risk prostate cancer. For most patients who underwent ...

THE TOPIC OF THIS PROPOSAL IS THE DESIGN OF AN ENVIRONMENTALCONTROL SYSTEM FOR THE MORE THAN TWO MILLION INDIVIDUALS IN THE UNITED STATES WHOSE PHYSICAL AND/OR MENTAL IMPAIRMENTS ARE SO SEVERE THAT THEY ARE UNABLE TO FUNCTION IN THEIR ENVIRONMENT IN A NORMAL AND EFFECTIVE MANNER. A TWO-YEAR COLLABORATIVE RESEARCH EFFORT BETWEEN THE BIOENGINEERING PROGRAM AT THE NATIONAL HEADQUARTERS OF THE ASSOCIA ...

In order to maintain acoustic advantage, submarine crews need to assess acoustic vulnerability for historical and planned tracks and own ship noisy evolutions. A TDA or TDAs that produce acoustic advantage and vulnerability overlays for the geographic plot are essential to this. Our Phase I effort will develop a MATLAB-based TDA tool engine that when provided with the required inputs (own ship, en ...