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This project focuses on developing a magnetic resonance imaging (MRI) contrast agent that may increase the detection of tagged cells by a factor of 10-100. The ability to noninvasively track specifically labeled (tagged) cells, enables a researcher or medical treatment professional to dynamically monitor the delivery and targeted application of medicinal and bio-reactive agents.

Standards and specifications are widely used in government and industry to define requirements for products and processes and insure interoperability, safety, and quality of industrial and domestic products. Specifications and standards documents almost always cross-reference other standards and specification. Taken together, the web of interdependent standards forms an immensely important knowled ...

ABSTRACT: The overall objective of this project is to develop scalable simulation components that effectively model the meso-scale physics of heterogeneous energetic materials subject to dynamic shock loading including matrix debonding, void collapse, and damage due to crystal to crystal interactions, and bridges the meso-scale to the macro-scale for system scale simulations of the transition to d ...

Integrated Clinical Environments (ICE) rely heavily on medical devices that need to be protected from security threats without compromising patient health and safety. There is a need to assess clinical workflow configurations in terms of security, usability, and efficiency. Currently, each medical device has its own security controls. Access to multiple devices in the integrated environment requir ...

Health Delivery Organizations, including the Military Health System, are increasingly using networked medical devices to benefit from improved information accuracy, lowered costs, and improved patient outcomes. These benefits, however, are threatened by the security risks posed by the interactions between the networked devices, and their connection to IT systems which are at risk of cyber attack. ...

ABSTRACT:The objective of SHIH-TSU is to develop and commercialize a hypervisor-based patch management system. The capability is to support enterprise virtualization solutions, automatic updating, security update testing, facilitate the installation and management of Windows updates, and be able to update arbitrary, user-defined software.SHIH-TSU will extend the research performed in SHIH-TSU Phas ...

Integrated clinical environments (ICEs) include medical devices and systems that process, store, and share sensitive data over networks. This requires that security concerns and data privacy be addressed. However, the design of such controls can conflict with the usability of the medical devices, especially in high pressure, time-sensitive conditions such as acute clinical and remote care settings ...

ABSTRACT: Designing propulsion devices and munitions for precise operational performance demands control and manipulation of energy released by explosive materials. It is well recognized that the initiation of energetic materials in explosives applications depends sensitively on hot-spots that originate from various heterogeneities at the meso (particle)-scale such as voids, defects, dislocations ...

About 40% of trauma-related deaths are related to rapid onset of coagulopathy and the vast majority of trauma patients are coagulopathic at the time of death. Lynntech proposes to develop a novel, easy-to-use and cost effective device for simultaneous quantitative real-time detection of multiple proteins involved in the hemostatic mechanism, using human unprocessed whole blood as the input sample. ...

ABSTRACT: The current state-of-the-art for heat exchanger (HEX) analysis and design relies on analytical approaches which are difficult to scale and highly empirical, thus making the ability to optimize advanced heat transfer devices improbable without comprehensive characterization efforts. The design standard for predicting heat exchanger performance is a set of empirical data developed more th ...