Award Data

DESCRIPTION provided by applicant Severe loss of vision occurs due to age related macular degeneration AMD and approximately million people in the US have some form of AMD which is expected to double by Most of the current clinical treatments are primarily focused on slowing down the progression of the disease as there is neither a cure that can stop the degeneration nor a therapy ...

DESCRIPTION provided by applicant Develop predictive human cardiomyocyte based all optical assay for cardiotoxicity Cardiotoxicity is the leading cause of safety driven withdrawal a all stages and limitation of drug compounds The current cardiac safety paradigm nonclinical guidance ICH S B focuses on in vitro hERG assays which prove to be suboptimal in predicting a compoundandapos s cardioto ...

DESCRIPTION provided by applicant The goal of this Fast Track Phase I II SBIR is to test a novel extracorporeal system for delivering mesenchymal stem cell MSC secretions to treat acute myocardial infarction MI We will use the Sentien proprietary extracorporeal delivery system to treat swine subjected to a clinically relevant model of MI The project specific aims are Simulated blood ...

DESCRIPTION provided by applicant Transcranial Direct Current Stimulation tDCS with weak currents is a non invasive low cost and well tolerated technique producing lasting functional changes in the central nervous system There is increasing evidence supporting the use of tDCS to improve stroke rehabilitation Behavioral and therapeutic outcomes of tDCS depend on the brain areas being targe ...

DESCRIPTION provided by applicant Primary Prevention of Sexual Violence among College Students This Fast Track SBIR proposal is designed to address the urgent need for an effective primary prevention approach to the problem of sexual violence among college students It is estimated that in every college women has been sexually assaulted while in college There is a dearth of primary preven ...

DESCRIPTION provided by applicant According to the Oral Cancer OC Foundation oral and pharyngeal cancer will cause deaths this year in the US killing roughly one person per hour Currently cisplatin CIS is at the forefront of platinum based chemotherapeutics for treating OC However its efficacy is often hindered by its significant systemic toxicity as a resut of traditional bolus ...

DESCRIPTION provided by applicant PTI is a novel compound with a novel target designed to treat and slow the progression of Alzheimerandapos s disease AD PTI works by binding extremely tightly to a particular site on filamin A FLNA a protein we recently demonstrated to be critical to beta amyloidandapos s toxicity Beta amyloid A exerts its toxic effects by binding and h ...

This project focuses on developing a magnetic resonance imaging (MRI) contrast agent that may increase the detection of tagged cells by a factor of 10-100. The ability to noninvasively track specifically labeled (tagged) cells, enables a researcher or medical treatment professional to dynamically monitor the delivery and targeted application of medicinal and bio-reactive agents.

Categorical theory has recently been successfully applied to translate information from one computer system to another. Researchers at MIT have developed a prototype software tool based on category theory for solving information-integration programs. The tool has successfully solved small-scale information-integration problems including a problem identified by NIST about enriching the manufacturin ...

Standards and specifications are widely used in government and industry to define requirements for products and processes and insure interoperability, safety, and quality of industrial and domestic products. Specifications and standards documents almost always cross-reference other standards and specification. Taken together, the web of interdependent standards forms an immensely important knowled ...