Award Data

Boulder Nonlinear Systems BNS and Prof Edward Boyden s Synthetic Neurobiology Group at the Massachusetts Institute of Technology MIT Media Lab propose to develop a new liquid crystal spatial light modulator SLM capable generating high resolution holograms to overcome the imaging gap that currently divides cellular level optogenetic techniques and whole brain techniques to improve function ...

The United States has the highest rate of incarceration in the world There are over state and federal prisons housing over million prisoners in the United States The demographics of the prison population are shifting Longer sentences and constrained options for early release compound this trend The older adult segment of prison populations has more than tripled since The health ...

DESCRIPTION provided by applicant Hiltonol poly ICLC is a stabilized dsRNA therapeutic viral mimic or andapos danger signalandapos that activates multiple elements of innate and adaptive immunity It is a standalone immunomodulator but when properly combined with antigen it generates a comprehensive Th weighted immune response best suited for antiviral and antitumor action This project ...

Among the measures against drunk driving available to policy makers and prevention practitionersResponsible Beverage ServiceRBStraining has shown promiseIn these programsalcohol servers are educated in a number of techniquesincluding correct identification checkingrecognizing signs of intoxication in patronsand managing patrons via drink counting techniques to safely keep them under Driving While ...

Novel Methacrylate Thiol Ene Composites for Dental Restorative Materials As the demand for aesthetically pleasing restorative materials has increased so has the desire and demand for improved performance Despite their increasing prevalence the methacrylate resin phase for the vast majority of these materials has remained largely unaltered since Bowen first proposed the materials nearly year ...

Summary Nearly million wounds are treated in U S emergency departments every year Skin wounds such as severe burns large trauma wounds or non healing chronic wounds that are too extensive or complex to close by natural healing are often reconstructed using autologous skin grafts Although autologous skin grafts are currently the gold standard in complex wound repair there are significant ...

PROJECT SUMMARY The Hemagglutination assay HA and Hemagglutination Inhibition HI assay are widely used methods for characterizing viruses bacteria and antibodies The World Health Organization recently recommended that HI remain the gold standard method for influenza seroepidemiology Although the HA and HI assays are applied worldwide they have the disadvantages of manual plate reading no ...

DESCRIPTION provided by applicant New therapeutic agents are urgently needed for the treatment of sickle cell disease the worldandapos s most common genetic disease Our long term goal is to develop a botanical drug SCD for use in children and adults that slows or stops disease progression Sickle cell disease affects approximately people in the United States and millions worldw ...

DESCRIPTION provided by applicant We propose to develop a small fully integrated ultra sensitive commercial magnetometer that will merge the multi use and cost effective attributes of present EEG electrodes with the sensitivity of SQUID sensors Our device referred to as a magnetrode will combine reliable autonomous operation with straightforward multi channel integration for a robust MEG ...

DESCRIPTION provided by applicant A Phase II SBIR program of preclinical development is proposed for the development of an active specific immunotherapeutic called Cellariumandquot for treatment of glial cell based cancers Successful completion of this project will confirm therapeutic effect and pre clinical safety of the vaccine in preparation for first in human studies Upon demonstration of ...