Award Data

DESCRIPTION (provided by applicant): The long-term goal of the project is to bring to the market a new tool for prostate cancer screening, the Prostate Mechanical Imager (PMI), which provides real time 3-D reconstruction of prostate capturing its geometrical and mechanical characteristics and aids in detecting tissue abnormalities. The current PMI prototype has undergone several progressions of ha ...

DESCRIPTION (provided by applicant): Identification of Human Leukocyte Antigens, HLA, for matching of kidney and bone marrow donors and recipients is mandatory for transplantation. Many allele combinations fail to be resolved with current typing methods.

DESCRIPTION (provided by applicant): The objective of this project is to develop Intelligent Electrical Stimulator platform technology, which will allow for an automatic adjustment of the stimulator signal based on physical, physiological and/or biochemical parameters measured. This would allow for optimization of a long term treatment, as well as for an on demand treatment, if the conditions in ...

DESCRIPTION (provided by applicant): Since inadequate cleaning is the main cause of failure in sterilizing flexible endoscopes, cardinal modification of existing cleaning methods is urgently needed. During the Phase I (Grant # 1R43DK58622-01) and Phase II (Grant # 2R44DK58622-02) studies, Novaflux developed processes and devices based on its novel turbulent two-phase flow technology for cleaning e ...

DESCRIPTION (provided by applicant): Early detection of breast cancer remains one of the most significant challenges in health care. The tactile breast imager (TBI) is a promising solution that electronically captures the sense of touch to provide a qu

DESCRIPTIONprovided by applicantThe clinical problemBreast cancer is the commonest cancer in womenin whom it is second only to lung cancer as a cause of cancer deathMammography is the mainstay of screening for breast cancerthough its value is limited by its large number of false positive and false negative findingsA new solution the problemThe combination of two diagnostic tests with different bio ...

DESCRIPTION (provided by applicant): Existing dialyzer reprocessing methods should be re-examined by including additional requirements to ensure effective recovery of middle solute clearance for every dialysis treatment. Thus, cardinal modifications of dialyzer reprocessing technology are urgently needed to satisfy effective clearance of various uremic retention solutes other than urea. The NovaTr ...

DESCRIPTION provided by applicant Neonatal hyperbilirubinemia occurs in almost all newborns and may be benign if its progression to extreme hyperbilirubinemia is recognized monitored and prevented or managed in a timely manner Neonatal jaundice carries the risk of neurotoxicity due to the deposition of bilirubin in the central nervous system Most of the bilirubin in plasma is bound to pla ...

DESCRIPTION (provided by applicant): This Phase II SBIR project is focused at the development of a high-throughput screening method and instrument for drug discovery using miniaturized, cell-based assays. For developing new drugs against complex dise

Project Summary This direct Phase II SBIR proposal focuses on the development of recombinant human MGrhMGa novel tissue repair proteinas a therapeutic candidate targeting injury of renal epithelium to protect against acute kidney injuryAKIAKI is commonly encountered in the hospital and outpatient settings and is associated with a high rate of mortalityCurrentlythere is no effective means for preve ...