Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Development of a human cellular TBK1 model for drug discovery in ALS

    SBC: Quralis Corporation            Topic: 103

    Program SummaryAmyotrophic lateral sclerosisALSaffects an estimatedindividuals in theUnited States andworldwideThe disease is characterized by loss of motor neurons leadingto loss of muscle control and muscle wastingPatients typically progress from diagnosis todeath inyearsWhile there are two approved therapies to treat ALStheir effectsare limitedThe lack of available treatments for ALS patients r ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A Prescription Digital Therapeutic to Promote Adherence to Buprenorphine Pharmacotherapy for Patients with Opioid Use Disorder

    SBC: Pear Therapeutics, Inc.            Topic: NIDA

    PROJECT SUMMARY ABSTRACT Opioid Use DisorderOUDis a key driver of the current opioid epidemic in the United StatesNearlyof individuals with OUD do not receive treatmentBuprenorphine Medication Assisted TreatmentMATis an effective form of care for OUDBuprenorphine ameliorates craving and withdrawaland reduces illicit opioid usemortalityand problems associated with drug useHoweveradoption of bupreno ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Noninvasive Brain Stimulation for Treating Addiction

    SBC: HIGHLAND INSTRUMENTS            Topic: NIDA

    ProprietaryThis proposal includes trade secrets and other proprietary or confidential information of Highland Instruments and is being provided for use by the National Institutes of HealthNIHfor the sole purpose of evaluating this SBIR proposalNo other rights are conferredThis proposal andthe trade secrets and other proprietary or confidential information contained herein shal further not be discl ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Targeting neurotoxic alpha-synuclein aggregates for Parkinson's disease therapy.

    SBC: Vova Ida, LLC            Topic: 999

    SUMMARYParkinsonandapos s diseasePDis the second most prevalent neurodegenerative disorder after Alzheimerandapos s diseaseADaffecting more thanmillion people in the United StatesBecause age is the major risk factorthe prevalence of both diseases is steadily increasing as our population agesPD belongs to the group of protein misfolding neurodegenerative diseases that are due to the misfolding and ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Enabling of a Wireless and Remotely Monitored Deep Brain Stimulation System through the Internet of Medical Things for Parkinson's Disease Patients

    SBC: BioNet Sonar            Topic: 103

    Project Summary The objective of this project is to demonstrate feasibility of a novel platform technology using ultrasonic waves for wireless bidirectional real time communication and powering of a Bilateral Deep Brain StimulationDBSsystem with remote patient monitoringDBS has become an established neurosurgical procedure with overpatients treated worldwideDBS has been shown to improve Parkinsona ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Validation of a Cranial Neurosurgery Simulator and Assessment of Minimally Invasive Techniques

    SBC: Simulated Inanimate Models LLC            Topic: 103

    Project SummarySimulation training is unique in its ability for repetitive practice of a wide variety of scenarios and to reflect on performance without jeopardizing a patient s safetySurgical skills simulators have been successful in bridging gaps of the current training modelhoweverthese simulators fall short of offering a complete operative experienceOperative exposure with live patients still ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Long-acting ghrelin for neuropathy

    SBC: Extend Biosciences Inc.            Topic: 103

    Project Summary Neuropathy is an acquired disease that can lead to debilitating chronic pain affectingtoof the general populationAmong patients with symptomatic neuropathysleep disturbancesanxiety and depression are commonnegatively impacting quality of lifeDiabetes is a leading cause of neuropathy and is expected to become more prevalent as the incidence of diabetes increasesChemotherapy induced ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A novel TRP modulator YB-2 to fight opioid crisis and treat chronic pain

    SBC: YOUNG BIOPHARMA, LLC            Topic: NIDA

    Abstract There aremillion people living with chronic pain in the U Swhich is more than the combined prevalence of cancerdiabetes and heart diseaseChronic pain is the number one cause of long term disability in the U STo make matters worsethe prolific use of opioids to treat chronic pain has exacerbated drug abuse and addictionplacing opioid painkillers at the heart of a raging crisis that tookAmer ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Molecular Biomarkers of Dangerous Intracranial Aneurysms

    SBC: NEUROVASCULAR DIAGNOSTICS, INC.            Topic: 103

    Abstract Rupture of intracranial aneurysmsIAscauses intracranial hemorrhaging that leads to high rates of neurological deficits and deathAlthough rupture rates are lowclinicians must decide whether to treat or monitor these potentially dangerous lesionsIn the current clinical practicethe most common metric to measure risk of rupture is aneurysm sizemm ormmHoweverclinical data show that small aneur ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A deep learning platform to evaluate the reliability of scientific claims by citation analysis.

    SBC: Scite, Inc.            Topic: NIDA

    The opioid epidemic in the United States has been traced to aletter reporting in the prestigious New England Journal of Medicine that synthetic opioids are not addictiveA belated citation analysis led the journal to append this letter with a warning this letter has beenheavily and uncritically citedas evidence that addiction is rare with opioid therapyThis epidemic is but one example of how unreli ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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