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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. First-in-class TREM-1 inhibitors in combination therapy for pancreatic cancer

    SBC: SIGNABLOK, INC.            Topic: 102

    Project Summary/Abstract Carcinoma of the pancreas, or pancreatic cancer (PC), is the third leading cause of cancer-related death in the US. Despite recent advances in the current treatments that include surgery, radiation therapy, chemo- and immunotherapy, the 5-year survival rate is as low as 9%. The long-term goal of this project is to develop a first-in-class, efficient and well tolerable ther ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Product Development of Intensity Modulation for Bolus Electron Conformal Therapy

    SBC: Decimal, LLC            Topic: 102

    Project Summary/Abstract Objective: This project aims to elevate electron beam therapy (EBT) technology, which provides effective radiation treatment for superficial cancers (depthandlt;6 cm), to that of other external beam radiotherapies (XRT), e.g. x-rays and protons, by bringing electron intensity modulation into the clinic. Challenge: Approximately 10% of radiotherapy patients (173,000 in U ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Highly Multiplexed Nanoscale Mass Spectrometric Imaging of Cancer Tissues

    SBC: AMBERGEN, INC            Topic: NCI

    Summary/Abstract Mass spectrometry (MS) has played a leading role in the past three decades in the field of proteomics. A combination of innovative MS-based techniques has provided powerful tools for proteomic discovery including the ability to identify protein biomarkers in a complex sample, quantify changes in protein expression and characterize protein- protein interactions. A second important ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. An automated test for gestational diabetes based on glycated CD59

    SBC: Mellitus, LLC            Topic: 200

    Diabetes and pre-Diabetes are growing at an epidemic rate. Mellitus, LLC is developing a novel test for Gestational Diabetes (GDM) and Diabetes based on the novel biomarker, Glycated CD59 (GCD59), licensed exclusively to Mellitus from Harvard University. With nearly 4M annual pregnancies in the US and 130MM live births worldwide, GDM is a high public health priority because it is a major cause of ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a small molecule inhibitor of PAI-1 for the treatment of diffuse cutaneous systemic sclerosis

    SBC: MDI THERAPEUTICS INC            Topic: NIAMS

    This project will provide critical preclinical data for a novel therapeutic small molecule inhibitor of plasminogen activator inhibitor 1 (PAI-1) as a potential treatment for diffuse cutaneous systemic sclerosis with associated interstitial lung disease (dcSSc-ILD). SSc is a devastating disease of unknown etiology with no currently approved disease-modifying treatments; lung fibrosis (interstitial ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a novel small molecule-based approach for accelerated fracture repair in the aging skeleton

    SBC: CAYMAN CHEMICAL COMPANY, INCORPORATED            Topic: NIAMS

    PROJECT SUMMARY/ABSTRACT Approximately 6.3 million fractures occur in the United States each year, accounting for 16% of all musculoskeletal injuries and leading to well over 10 million hospital and physician offices visits. Up to 10% of fractures are recalcitrant and require surgical intervention for proper healing. The weakened bones in the growing geriatric population are contributing to the ri ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Innovative High Resolution Dental X-ray Imager

    SBC: RADIATION MONITORING DEVICES, INC.            Topic: 100

    AbstractRadiation Monitoring Devices (RMD) proposes to develop a new dental x-ray imager that will have all the advantages of a digital technology, retain the most desirable aspects of image quality that film emulsions provide, and most importantly, reduce dose to patients. The device will be a blend of two technologies – silicon based imaging arrays and semiconductor x-ray conversion layers. Th ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Bioresorbable Nanoparticles for Visual Detection of Early-Stage Dental Caries

    SBC: GreenMark Biomedical Inc.            Topic: NIDCR

    PROJECT SUMMARY/ABSTRACT This project responds to the need identified by NIDCR to develop improved methods to detect and predict progression of dental caries (tooth decay) to improve human health. Worldwide, caries is the most common chronic disease affecting almost everyone. Dental disease is a major cause of economic and social loss and leads to complications including pain, tooth loss and even ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Person-Centered Mobile App for AD/ADRD Family Caregivers

    SBC: RSV OPCO 5, INC.            Topic: NIA

    PROJECT SUMMARY More than 5 million people in the US suffer from AD/ADRD, and the Alzheimerandapos;s Association predicts that the number of sufferers will increase to as many as 14 million by 2050. New recommendations for the care of dementia place a strong focus on Person-Centered care. Family caregivers can play a vital role in supporting this approach, but they are already stretched. The Alzhe ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Precise Minimally InvasiveTreatment of VT Using Non-invasive Mapping.

    SBC: HEARTLANDER SURGICAL, INC.            Topic: NHLBI

    Project Summary Ventricular Tachycardia (VT) is a major public health problem associated with the majority of the 300,000 cases of sudden cardiac death in the United States each year. The best current therapy for VT involves drugs to reduce VT episodes plus implantation of a cardiac defibrilator (ICD) that prolongs life by terminating episodes of VT. Permanent cessation of VT can be achieved by ab ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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