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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Targeting neurotoxic alpha-synuclein aggregates for Parkinson's disease therapy.

    SBC: Vova Ida, LLC            Topic: 999

    SUMMARYParkinsonandapos s diseasePDis the second most prevalent neurodegenerative disorder after Alzheimerandapos s diseaseADaffecting more thanmillion people in the United StatesBecause age is the major risk factorthe prevalence of both diseases is steadily increasing as our population agesPD belongs to the group of protein misfolding neurodegenerative diseases that are due to the misfolding and ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Product Development of Intensity Modulation for Bolus Electron Conformal Therapy

    SBC: Decimal, LLC            Topic: 102

    Project Summary/Abstract Objective: This project aims to elevate electron beam therapy (EBT) technology, which provides effective radiation treatment for superficial cancers (depthandlt;6 cm), to that of other external beam radiotherapies (XRT), e.g. x-rays and protons, by bringing electron intensity modulation into the clinic. Challenge: Approximately 10% of radiotherapy patients (173,000 in U ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. An Integrated Genetic-Epigenetic Tool for the Prediction of CHD Incidence in African-Americans

    SBC: Cardio Diagnostics, LLC            Topic: NHLBI

    ABSTRACTHeart disease is the leading cause of death in the United StatesCoronary heart diseaseCHDis the most common type of heart diseaseEvery yearmillions of Americans suffer otherwise preventable cardiac events resulting indeaths and $billion dollars of economic damage each yearThe prevalence of CHD varies by ethnicityNeverthelessfortunatelyCHD related morbidity and mortality can be prevented th ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Targeting SWELL1 Signaling to Treat Obesity-Induced Type 2 Diabetes

    SBC: Senseion, LLC            Topic: 200

    Project Summary Abstract TypediabetesT Dis characterized by both a loss of insulin sensitivity of target tissuesfatskeletal muscleliverand ultimatelyimpaired insulin secretion from the pancreaticcellWe have identified a novel SWELLmediated signaling pathway that regulates both insulin sensitivity and insulin secretionwhereby SWELLloss of function can both negatively regulate insulin signaling in t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Phase 1 cross over biodistribution study of [203Pb]VMT01 for single photon emission computed tomography (SPECT) and [68Ga]VMT02 for positron emission tomography (PET) imaging of stage 4 melanoma

    SBC: VIEWPOINT MOLECULAR TARGETING, INC.            Topic: 102

    SIGNIFICANCE: Melanoma incidence is rising faster than any other cancer and metastatic melanoma is typically fatal. Responses to targeted and immunotherapies can be remarkable, but low response rates, acquired resistance, and adverse side effects limit long-term quality of life for these patients. The overall response rate to all therapies remains dismally near 50% and the 5-year survival is andlt ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. beta-Catenin inhibitors: A novel immuno-therapy for Colorectal Cancer

    SBC: Venn Therapeutics, LLC            Topic: 100

    ABSTRACT Although cancer immunotherapy is considered a great breakthrough in cancer therapya significant proportion of patients do not respond to these treatmentsRecent studies have shown that clinical benefits of the most potent immunotherapy lay in the presence of a T cell inflamed tumor microenvironment at baselinehot tumorDysregulated Wntcatenin signaling has been implicated in the lack of imm ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Low Cost Electrochemical Gas Phase Nitric Oxide Generator for Biomedical Applications

    SBC: NOTA Laboratories, Inc.            Topic: NHLBI

    ABSTRACTTherapeutic use of gas phase nitric oxideNOhas several important applications in medicineSince its first medical application more thanyears agoinhaled nitric oxideINOhas become a mainstay of intensive care for lung failure patientsAs a pulmonary vasodilatorINO is essential in neonatologylung transplantationand pulmonary hypertensionAs an inhaled antiseptic agentNO has been proposed in the ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A fast, scalable, cost-effective, single-stranded library protocol for cell-free DNA

    SBC: Claret Bioscience LLC            Topic: 102

    Project Summary Liquid biopsy is a potentially powerfulnon invasive approach for detectingclassifying and monitoring tumors by capturing cell free DNA molecules found circulating in blood and other bodily fluidsAny next generation sequencingNGSbased approach requires an efficient protocol for converting cell free DNA into a sequencing libraryNearly all currently available NGS library preparation m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Bioresorbable Nanoparticles for Visual Detection of Early-Stage Dental Caries

    SBC: GreenMark Biomedical Inc.            Topic: NIDCR

    PROJECT SUMMARY/ABSTRACT This project responds to the need identified by NIDCR to develop improved methods to detect and predict progression of dental caries (tooth decay) to improve human health. Worldwide, caries is the most common chronic disease affecting almost everyone. Dental disease is a major cause of economic and social loss and leads to complications including pain, tooth loss and even ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Automated Intestinal Electrical Stimulation for Diabetes

    SBC: TRANSTIMULATION RESEARCH INC            Topic: 200

    Diabetes affects more than 9% of Americans and costs over $300 billion in 2017 in USA. Medical therapies have limitations in treating diabetic patients with obesity due their common side effects of weight gain. Bariatric surgery has been proposed for treating diabetic patients with promising outcomes. In this project, we propose a novel method of intestinal electrical stimulation (IES) for treatin ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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