Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Targeting neurotoxic alpha-synuclein aggregates for Parkinson's disease therapy.

    SBC: Vova Ida, LLC            Topic: 999

    SUMMARYParkinsonandapos s diseasePDis the second most prevalent neurodegenerative disorder after Alzheimerandapos s diseaseADaffecting more thanmillion people in the United StatesBecause age is the major risk factorthe prevalence of both diseases is steadily increasing as our population agesPD belongs to the group of protein misfolding neurodegenerative diseases that are due to the misfolding and ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Developing novel fibrillin biomarkers for aortic disease

    SBC: Virogenomics BioDevelopment Inc            Topic: NHLBI

    PROJECT SUMMARY In the United Statesaortic aneurysmal disease ranks among the topleading causes of deathPatients with aortic aneurysmsAAsare typically asymptomatic until dissection and then symptoms resemble other ailmentswhich can delay a correct diagnosisMortality associated with aortic dissectionADis high and rapid due to rupture of the aortaReducing mortality from aneurysmal disease requires i ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Technology-based Training Tool for an Empirically- Supported Group-Based HIV and STI Prevention Intervention for Juvenile Offenders

    SBC: Oregon Research Behavioral Intervention Strategies, INC            Topic: 102

    Summary AbstractYouth under ageinvolved in the criminal justice system are disproportionately minorities and affected by substance abusemental illnessand HIV STIMost young offenders are released on community supervision without the STImental healthor substance use screeningdiagnosisand treatment afforded detained youthdespite similar rates of risk behaviorTheir long term trajectory is poorthe cost ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Product Development of Intensity Modulation for Bolus Electron Conformal Therapy

    SBC: Decimal, LLC            Topic: 102

    Project Summary Abstract ObjectiveThis project aims to elevate electron beam therapyEBTtechnologywhich provides effective radiation treatment for superficial cancersdepthandltcmto that of other external beam radiotherapiesXRTe gx rays and protonsby bringing electron intensity modulation into the clinicChallengeApproximatelyof radiotherapy patientsin USA annuallyreceive EBT for a portion of their t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School

    SBC: Oregon Research Behavioral Intervention Strategies, INC            Topic: 400

    Abstract Deviant peer affiliation is one of the most important predictors of alcohol use in adolescenceThese affiliations often arise when socially marginalized youth self aggregate and reinforce alcohol use and other deviant activityi edeviant peer clusteringEven though the field has developed efficacious school based prevention programsprogram effects are generally smalland these programs can be ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. An Integrated Genetic-Epigenetic Tool for the Prediction of CHD Incidence in African-Americans

    SBC: Cardio Diagnostics, LLC            Topic: NHLBI

    ABSTRACTHeart disease is the leading cause of death in the United StatesCoronary heart diseaseCHDis the most common type of heart diseaseEvery yearmillions of Americans suffer otherwise preventable cardiac events resulting indeaths and $billion dollars of economic damage each yearThe prevalence of CHD varies by ethnicityNeverthelessfortunatelyCHD related morbidity and mortality can be prevented th ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting SWELL1 Signaling to Treat Obesity-Induced Type 2 Diabetes

    SBC: Senseion, LLC            Topic: 200

    Project Summary Abstract TypediabetesT Dis characterized by both a loss of insulin sensitivity of target tissuesfatskeletal muscleliverand ultimatelyimpaired insulin secretion from the pancreaticcellWe have identified a novel SWELLmediated signaling pathway that regulates both insulin sensitivity and insulin secretionwhereby SWELLloss of function can both negatively regulate insulin signaling in t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Phase 1 cross over biodistribution study of [203Pb]VMT01 for single photon emission computed tomography (SPECT) and [68Ga]VMT02 for positron emission tomography (PET) imaging of stage 4 melanoma

    SBC: VIEWPOINT MOLECULAR TARGETING, LLC            Topic: 102

    SIGNIFICANCEMelanoma incidence is rising faster than any other cancer and metastatic melanoma is typically fatalResponses to targeted and immunotherapies can be remarkablebut low response ratesacquired resistanceand adverse side effects limit long term quality of life for these patientsThe overall response rate to all therapies remains dismally nearand theyear survival is andltPreclinical studies ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a miniaturized, single-port automated insulin delivery system utilizing a glucose sensing catheter, ultra-concentrated insulin, and an optimized control algorithm

    SBC: Pacific Diabetes Technologies            Topic: 200

    ABSTRACT SignificanceThere are overmillion people with insulin treated diabetes in the United States who represent a disproportionately large share of the $B in direct medical costs attributable to diabetesThe use of continuous glucose monitoringCGMhas been shown to reduce HbA c levelsa proven predictor of health outcomes within this populationwith the greatest improvement achieved when CGM is cou ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. beta-Catenin inhibitors: A novel immuno-therapy for Colorectal Cancer

    SBC: Venn Therapeutics, LLC            Topic: 100

    ABSTRACT Although cancer immunotherapy is considered a great breakthrough in cancer therapya significant proportion of patients do not respond to these treatmentsRecent studies have shown that clinical benefits of the most potent immunotherapy lay in the presence of a T cell inflamed tumor microenvironment at baselinehot tumorDysregulated Wntcatenin signaling has been implicated in the lack of imm ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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