Award Data

Our biosensor is made of silicon nanowire arrays functionalized with antibodies to measure the concentration of specific proteins. In this grant we will take a sensor that has been demonstrated for use in measuring a set of generic host cell proteins and we will apply the sensor to measure a set of proteins for a specific cell line. In doing so, we will demonstrate the utility of our sensor to be ...

In this Small Business Innovative Research (SBIR) effort, Nikira Labs Inc. proposes to develop a compact Raman fiber optic probe with inline spectral filtering that improves fiber-coupled Raman measurements by filtering out Raman scattering from the excitation fiber and elastically scattered laser light from the collection fibers. The technology will enable compact fiber probes for Raman studies i ...

Phase I has proven that the current setup achieves better than 8mm spatial resolution for 2.2MeV prompt gammas. However, 1mm spatial resolution presents a significant challenge for the current setup due in part to limited timing resolution and count rate. A new analog ASIC will be developed to replace the current analog ASIC that will have better timing resolution and deliver higher count rates. I ...

Fullmoon has the first chip-level sensors capable of identifying and quantifying molecules in the air. At the core of our technology are printed voltammetric sensors, which are operated using cyclic voltammetry, an electrochemical technique that probes for the redox potential, a unique signature of molecules. We have demonstrated this sensing principle for the detection of carbon monoxide and meth ...

Industrial facilities, manufacturing plants, and electric power plants that burn fossil fuels exhaust the combustion products to atmosphere through their smokestacks. Stack pollutant emissions are quantified using manual testing methods developed in the 1960s, which are prone to error if non-axial flow exists in a stack.Recently, NIST has been working on an improved technique of performing 3D flow ...

To evaluate the technical feasibility of prompt gamma neutron activation (PGAA) as an alternative to a set of standard destructive tests of concrete petrography including aggregate type, water/cement ratio, aggregate/binder ratio, density, chloride content and chloride bulk diffusion constant; and to determine the specifications for the design of a dedicated commercial laboratory-based PGAA facili ...

This project is devoted to development of a manufacturing technique of slow neutron Germanium mosaic monochromators with reflectivity exceeding reflectivity of pyrolytic graphite crystals. The manufacturing technique utilizes optimized high temperature plastic deformation of large single Germanium crystals to produce mosaic monochromators. Preliminary test on 70 mm diameter Ge samples with 111 ori ...

Categorical theory has recently been successfully applied to translate information from one computer system to another. Researchers at MIT have developed a prototype software tool based on category theory for solving information-integration programs. The tool has successfully solved small-scale information-integration problems including a problem identified by NIST about enriching the manufacturin ...

Nodexus is commercializing next-generation bioinstrumentation for researchers, clinicians, and the biotech industry at large. As development challenge involves a material switch to polymer-based microfluidics to improve robustness and reproducibility of measurements. Nodexus will develop new manufacturing processes for their microfluidic product suite that preserves surface functionalization while ...

This Automated Access Control Policy Testing System (A-ACPTS) project extends and transitions NIST’s Access Control Policy Tool (ACPT) toward commercialization. The core challenge is to research and develop an ACPT-based tool and a method of automating as many of the inputs into the model checking as possible, with the goal of making the testing more usable, less error-prone, and more efficient ...