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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Multimode Chiroptical Spectrometer for Nanoparticle Characterization

    SBC: Applied Nanofluorescence LLC            Topic: None

    This project will develop a new scientific instrument optimized for the advanced characterization of near-infrared fluorescent nanoparticles that can exist as left- or right-handed structures (enantiomers). Single-walled carbon nanotubes (SWCNTs) are the leading current example of such nanomaterials. Applied NanoFluorescence, LLC (ANF) proposes a novel multi-mode chiroptical spectrometer that can ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  2. Advanced Manufacturing and Material Measurements Software Tool Weave ™ for the Acceleration and Automation of SEM Image Analysis in the Semiconductor Industry

    SBC: Sandbox Semiconductor Incorporated            Topic: None

    In this Phase I SBIR proposal, SandBox Semiconductor™ proposes to develop an Advanced Manufacturing and Material Measurements software tool called Weave ™ for accelerating and automating SEM image analysis for the semiconductor industry. During the development of a new manufacturing process line for a semiconductor device, tens of thousands of scanning electron microscopy (SEM) images are take ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  3. Gap-Free Model-Based Engineering for Manufacturing and Analysis: Digital Thread without Translation

    SBC: Nvariate, Inc.            Topic: None

    Modern Model-Based Enterprise / Engineering (MBE) systems rely on freeform surfaces built as complex combinations of geometric primitives to define engineered objects. Unfortunately, the intersection of freeform surfaces in MBE applications results in highly approximated solutions, degrading models that cost billions annually by US industry to fix. Current technology limits the abilities of users ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  4. Ambient light activatable opsin based therapy for age-related macular degeneration

    SBC: NANOSCOPE TECHNOLOGIES LLC            Topic: N

    DESCRIPTION provided by applicant Severe loss of vision occurs due to age related macular degeneration AMD and approximately million people in the US have some form of AMD which is expected to double by Most of the current clinical treatments are primarily focused on slowing down the progression of the disease as there is neither a cure that can stop the degeneration nor a therapy ...

    SBIR Phase I 2015 Department of Health and Human Services
  5. IND- and NDA-enabling toxicology studies for PTI-125, a novel small molecule for Alzheimer's disease

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIA

    DESCRIPTION provided by applicant PTI is a novel compound with a novel target designed to treat and slow the progression of Alzheimerandapos s disease AD PTI works by binding extremely tightly to a particular site on filamin A FLNA a protein we recently demonstrated to be critical to beta amyloidandapos s toxicity Beta amyloid A exerts its toxic effects by binding and h ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Embedded Access to Signing of Science Terms and Definitions

    SBC: Vcom3D, Inc.            Topic: NA

    Deaf and hard-of-hearing students may lag behind their hearing peers in English literacy and in science, technology, engineering, and mathematics (STEM). Evaluations in classroom and informal environments have demonstrated the efficacy of the dictionaries in increasing student engagement and mastery of math and science content and vocabulary. This project develops a cloud-based service and corresp ...

    SBIR Phase I 2015 Department of Health and Human Services
  7. Biocompatible retinal prosthesis based on a conjugated polymer photoactive layer

    SBC: Lynntech Inc.            Topic: N

    DESCRIPTION provided by applicant This proposal is in response to a specific approved topic area as defined by the NEI in Appendix A National Institutes of Health SBA Approved SBIR STTR Topics for Awards over Statutory Budget Limitations from the PHS Omnibus Solicitation for SBIR STTR Grant Applications This Phase I feasibility study is an advanced technology project with a clearly id ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Novel selective alpha4beta2 nicotinic receptor antagonists for smoking cessation

    SBC: ASSUAGE PHARMACEUTICALS, INC.            Topic: NIDA

    DESCRIPTION provided by applicant Smoking remains the number one avoidable cause of death in the United States and costs the economy tens of billions of dollars every year Current therapies include nicotine replacement with a patch or gum inhibition of the dopamine system with bupropion and partial activation of the neuronal nicotinic acetylcholine receptor nAChR with varenicline Non ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Combination Immunotherapy of a Novel Superagonist IL-15 Complex and Anti-CD20 Antibody for Indolent Non-Hodgkin Lymphoma

    SBC: Altor Bioscience LLC            Topic: 102

    DESCRIPTION provided by applicant Non Hodgkin lymphoma NHL is the most commonly diagnosed hematologic malignancy in the U S with over new cases and about deaths due to NHL expected in Over one third of all cases are slow growing or indolent NHL iNHL which affect older adults and typically present as advanced disease The initial treatment of iNHL consists of an anti CD ...

    SBIR Phase II 2015 Department of Health and Human Services
  10. Developing A Novel Therapy for Diabetic Retinopathy

    SBC: Charlesson, LLC            Topic: W

    DESCRIPTION provided by applicant Diabetic retinopathy DR is a common complication of diabetes and a leading cause of vision loss in the United States Although the anti vascular endothelial growth factor VEGF drugs have shown impressive efficacies on wet age related macular degeneration AMD they are only effective in approximately of patients with DR likely due to the multi factori ...

    SBIR Phase II 2015 Department of Health and Human Services

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