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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Extending a digital risk mitigation intervention for workers deployed in diverse post-flood environments to address unique SAR-CoV-2 virus infection exposure risks in construction workplaces

    SBC: Radiant Creative Group, LLC            Topic: R

    ABSTRACT Flooding events continue to increase in both frequency and intensity. Workers involved in post-flood reconstruction work are at increased risk of adverse health effects due to respiratory exposures and other hazards. With the advent of the SARS-CoV-2 virus into the global community, these workers are even more at risk for severe illness. Proposed e-learning platform “Pocket Ark” provi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Determining Effectiveness of V-10 Self-Assembling Pro-Angiogenic Peptide in Re-Vascularizing and Accelerating Wound-Healing in a BBZDR Rat Model of Diabetic Foot Ulceration

    SBC: NANGIOTX INC            Topic: NIDDK

    Project Summary / Abstract NangioTx has developed a patented technology for promoting neovascularization in ischemic tissues. Its lead compound is a 33-amino-acid pro-angiogenic peptide V-10, which, when injected into an ischemic tissue microenvironment, generates mature microvasculature, aiding tissue regeneration. A proof of concept for such tissue regeneration has been obtained in a murine hind ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Development and Optimization of MNK Inhibitors for the Treatment of Neuropathic Pain

    SBC: 4E THERAPEUTICS, INC.            Topic: 104

    Abstract The goal of this project is to develop an optimized MNK inhibitor for neuropathic pain treatment. MNK is a kinase that phosphorylates eIF4E to control the translation of a distinct subset of mRNAs. Our focus on this target for neuropathic pain is grounded in evidence that MNK-eIF4E signaling is activated in nociceptors upon exposure to pain promoting cytokines and growth factors as well a ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a novel therapy for mitigation of the irradiation-inducedgastrointestinal syndrome

    SBC: BioIncept, LLC            Topic: NIAID

    Accidental radiation exposure as a result of terrorismindustrial accidentsor military actions is an increasing global threatExposure to IR in the dose range ofGy andGy toGy results in development of the hematopoieticHand gastrointestinalGIsubsyndromesrespectivelyof the acute radiation syndromeARSThe GI syndrome that follows GI ARS is the leading cause of death following higher doses of radiation e ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. mDGS: A novel mobile dietary guidance system for the management of type 2 diabetes using CGM-based hyperglycemia prediction

    SBC: Viocare, Inc.            Topic: 200

    More thanmillion U Sadults with typediabetesT DMdo not meet American Diabetes AssociationADAglycemic targets for glucose controlHealthcare costs related to diabetes were estimated at $billion inincluding $billion in direct medical costsPoorly regulated dietary intakewhich often results in chronic hyperglycemia and elevated HbA c levelscontributes substantially to this costAs suchmedical nutrition ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Engineered enzyme sensors based on allosteric regulation

    SBC: Pharmaseq, Inc            Topic: 400

    Summary It is proposed to develop an approach for constructing enzyme based sensors for detecting biomoleculesThe sensor is an enzyme modified by site directed mutagenesis to create a binding site specific for a target biomoleculeA library of engineered enzyme sensors is constructed to serve as a repository of potential bindersThe binding site is positioned in the immediate vicinity of the enzymea ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Stem Cells for Treating Acute Stroke

    SBC: SANERON CCEL THERAPEUTICS, INC.            Topic: 999

    ABSTRACT SUMMARY In previous studies we identified novel non hematopoietic umbilical cord blood stem cellsnhUCBSCsthat could be expanded to high passages and exhibit restorative properties following ischemic brain injury repairWe found that the high passaged cells were equivalentif not even betterthan the low passaged nh UCBSCsThis finding suggests that these cells can serve as a source of highly ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development of an M Protein-Deficient Respiratory Syncytial Virus Vaccine for Aerosolized Vaccination of the Lung

    SBC: HEARTLAND VACCINES LLC            Topic: NIAID

    Project Summary/Abstract Respiratory syncytial virus (RSV) is a major respiratory pathogen in human infants and elderly individuals. RSV infection is the principal cause of hospitalization of infants, and is a leading cause of infant mortality worldwide. In elderly adults, RSV infection accounts for 10-15,000 deaths annually in the US alone. Despite the high impact of RSV, there is presently no li ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Telerehabilitation Combining Virtual Reality Adaptable Games and Drug Therapy for Early Alzheimer's Disease

    SBC: Bright Cloud International Corp            Topic: NIA

    PROJECT SUMMARY Objectives: The first objective is to develop a computer-based cognitive training system for individuals in the early stages of Alzheimer’s Disease. The product, a home-based custom Virtual Reality (VR) system will be developed, targeting cognitive domains (processing speed, executive functions, attention, language, memory) as well as depression. The system will incorporate a nov ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Integrin Activation as a Treatment for Leukocyte Adhesion Deficiencies

    SBC: 7 Hills Pharma LLC            Topic: NIAID

    Leukocyte adhesion deficiency type ILADis a rare and often fatal primary immunodeficiencyIt is caused by autosomal recessive mutations in the gene ITGBwhich encodes CDthe commonsubunitof thefamily of integrin cell adhesion molecules that are specifically expressed on cells of hematopoietic origin like leukocytesAs a result of decreased function ofintegrinsleukocytes cannot extravasate from the vas ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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