Award Data

THIS PROPOSAL SEEKS TO DEVELOP AND IMPLEMENT A DISTRIBUTED DATA MANAGEMENT NETWORK FOR CANCER CLINICAL TRIALS. THE NETWORK WILL BE MICROCOMPUTER BASED AND WILL HAVE AS ITS OBJECTIVE A CENTRALIZED DATABASE FOR MONITORING THE PROGRESSOF CLINICAL TRIALS. FEATURES WILL INCLUDE DATA ENTRY USING PREFORMATTED SCREENS, AUTOMATED ERROR CHECKING, EDITING FACILITIES, DATA SECURITY, AND DATA TRANSFER CAPABILI ...

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HEARING TESTING OF NEWBORNS AND INFANTS USING AUDITORY BRAINSTEM RESPONSES (ABR) HAS GAINED WIDESPREAD ACCEPTANCE AND HAS COME TO BE PREFERRED OVER OTHER LESS ACCURATE TECHNIQUES. ABR'S STRENGTH IS ITS DIRECT MEASUREMENT OF AUDITORY FUNCTION, WHICH RESULTS IN HIGH TEST SPECIFICITY AND SENSITIVITY. CLINICAL USE OF ABR, HOWEVER, IS STILL LIMITED BECAUSE OF THE PROFESSIONAL LABOR-INTENSIVE OPERATION ...

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THE LONG-TERM GOAL OF THIS APPLICATION IS TO DEVELOP DIMETHYLSUBERIMIDATE (DMS) AS AN ALTERNATIVE PULP THERAPY. FORMOCRESOL, THE DRUG MOST COMMONLY USED FOR TREATMENT OF CARIOUSLY EXPOSED PULPS OF THE PRIMARY DENTITION, IS TOXIC TO THE TREATED TISSUE, INDUCES ANTIGEN FORMATION AND SUBSEQUENT CHRONIC INFLAMMATION, IS RAPIDLY DISTRIBUTED SYSTEMICALLY, AND HAS MUTAGENIC POTENTIAL. FORMOCRESOL PULPOTO ...

IN CHEMICAL AND BIOLOGICAL SYSTEMS, IRON IS BOTH UBIQUITOUS AND HIGHLY REACTIVE. IN A VARIETY OF CIRCUMSTANCES, THERE IS GREAT NEED FOR NEW APPROACHES TO THE REMOVAL OF IRON OR THE CONTROL OF ITS REACTIVITY. BIOMEDICAL FRONTIERS HAS PRODUCED A SERIES OF HIGH MOLECULAR WEIGHT IRON CHELATORS BASED ON DERIVATION OF A NUMBER OF SUBSTRATES WITH DEFER- OXAMINE B. THIS CHELATOR HAS AN EXTREMELY HIGH AFFI ...

INTRAOCULAR LENS IMPLANTS HAVE RETURNED VISION TO MANY CATARACT PATIENTS. THESE IMPLANTS PROVIDE VISUAL ACUITY WITHOUT THE DISTORTION OR MAGNIFICATION THAT CAN RESULT FROMWEARING THICK-LENSED SPECTACLES OR CONTACT LENSES. HOWEVER,AS WITH ALL OTHER IMPLANTABLE DEVICES, THERE ARE PROBLEMS WITH THE INTERACTION OF THE SYNTHETIC LENSES WITH EYE TISSUES. INADVERTENT CONTACT BETWEEN THE LENS AND THE CORN ...

SERIOUS ATTENTION HAS BEEN FOCUSED ON THE USE OF ILLICIT DRUGS BY AMERICANS IN ALL WALKS OF LIFE. ONE OF THE MOST ABUSED DRUGS FOR OVER TWO DECADES HAS BEEN MARIJUANA, WHICH IS NOW BEING USED BY BLUE- AND WHITE-COLLAR WORKERS, MILITARY PERSONNEL, PROFESSIONAL ATHLETES, AND HIGH SCHOOL STUDENTS. BECAUSE OF THIS, MANY EMPLOYERS (INCLUDING THE U.S. MILITARY) ARE BEGINNING TO DEMAND THAT WORKERS SUSPE ...

BIO-METRIC SYSTEMS, INC. PROPOSES TO DEVELOP A SEMIQUANTITATIVE, NONLABORATORY ENZYME IMMUNOASSAY THAT IS EXPECTED TO BE SENSITIVE, RAPID, AND CONVENIENT TO USE. THIS IMMUNOASSAY WILL REQUIRE NO INSTRUMENTATION AND IS EXPECTED TO HAVE A SINGLE-STEP PROTOCOL: SIMPLY DIP THE APPARATUS IN THE SAMPLE, WAIT A PRESCRIBED TIME, AND OBSERVETHE RESULT. THE QUANTITY OF ANALYTE PRESENT IN THE TEST SAMPLE IS ...

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