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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Biosynthetic Degradable Textile for Soft Tissue Reconstruction

    SBC: Deep Blue Medical Advances, Inc.            Topic: 300

    AbstractBiosynthetic or synthetic degradable hernia mesh is the fastest growing segment of the hernia mesh marketreaching$M in sales inwith Bard controllingof the US marketfollowed by GoreNovus Scientificand EthiconWhile biosynthetic mesh may be used in any type of hernia repairit is most commonly used in ventral hernia repair cases where there is an increased risk of bacterial infectionThe reason ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Ablation of the pathogenic RNA transcript associated with myotonic dystrophy, DM1

    SBC: ENZERNA BIOSCIENCES LLC            Topic: NIAMS

    ABSTRACTMyotonic muscular dystrophyDMDis a genetic disorder characterized by muscle degeneration and weaknessIt is a common form of muscular dystrophy that generally begins in adulthoodUnfortunatelythere are no approved curative therapies for DMtreatments are largely palliativeThe more severe formmyotonic dystrophy typeDMis caused by theCTG n expansion in theUTR of the dystrophia myotonica protein ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A Comprehensive Newborn Screening Solution for Duchenne and Congenital Muscular Dystrophies

    SBC: BAEBIES, INC.            Topic: NICHD

    Congenital genetic abnormalities are a leading cause of childhood mortality and morbidity. While routine newborn screening (NBS) has dramatically improved health outcomes, many congenital disorders such as Duchenne muscular dystrophy (DMD) and other congenital muscular dystrophies (CMD) are not currently detected by routine NBS. Presymptomatic identification through NBS is critical to facilitate e ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A computational platform to improve the prioritization of drugs and target genes for therapeutic intervention

    SBC: Genetic Networks, LLC            Topic: 100

    Project Summary This project proposes further development of a computational discovery platform shown to quantifiably identify and prioritize both targets and compounds for therapeutic intervention, which will accelerate the development of newer, more effective drugs with fewer side-effects. This platform is based on a novel fusion of two state of the art computational approaches (phenolog mapping ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Adding SpO2 and Hemoglobin Determinations to Non-Invasive Hemodynamic Monitoring for Healthy Independent Living

    SBC: RFPi, Inc.            Topic: NHLBI

    Abstract Technologies to safelyeffectivelyand efficiently monitor clinical cardiovascular status in patients with one or more cardiovascular related diseases are an unmet need in healthcareSince small changes in clinical status can compound rapidlymonitoring a number of physiologic status parametersPSPssimultaneously and trending their changes over time is crucial for early interventionin order to ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Advanced CLAD PERG system with minimal patient preparation for clinical settings

    SBC: JORVEC CORP.            Topic: N

    AbstractGlaucoma is one of a number of optic nerve diseases which lead to retinal ganglion cellsRGCdegenerationultimately manifesting in a functional loss of vision if left untreatedThere exist a number of therapeutic approaches to treat these conditionsbut there are currently no clinical methods to detect the onset of RGC dysfunctionThe Pattern ElectroretinogramPERGis the only established tool to ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Advanced development of a novel nanoparticle conjugate vaccine for Salmonella Paratyphi A

    SBC: KJ BIOSCIENCES LLC            Topic: NIAID

    Salmonella Paratyphi ASParatyphi Ais a major cause of life threatening enteric feverThere is no vaccine available against this pathogenIn the SBIR phase I studieswe have successfully demonstrated the technical feasibility of a novel nanoparticle conjugate vaccine candidate for SParatyphi AIt is based on O polysaccharideOPSantigen conjugated to a novel and highly advantageous nanoparticle protein c ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Advanced Simulated Patient Intelligent Response Engine (ASPIRE)

    SBC: VCOM3D INC            Topic: DHA191002

    The goal of medical simulation-based training such as high-fidelity manikin simulators, part task trainers, and screen-based virtual patients, is to approximate real-life treatment experiences without risk to live patients. While the use of sensors has ma

    SBIR Phase I 2019 Department of DefenseDefense Health Agency
  9. Advance Early Detection of Lupus Nephritis with ClearGold

    SBC: CLEARNANO INC            Topic: 400

    SummarySystemic lupus erythematosusSLEor lupus is an autoimmune disease that impacts more thanmillion people worldwideincludingmillion AmericansNearlyof these patients will develop lupus nephritiswhich can cause kidney failureAs a resultits financial burden to individual patient can reach $yearmuch higher than many other diseases because of kidney transplantationAlthough early treatment of lupus n ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A facile synthesis of optically pure disubstituted amino acids

    SBC: MONOMERCHEM, inc            Topic: 300

    Project Summary Enantiopuredisubstituted amino acidsEDAAsare valuable fundamental building blocks for medical research in both academics and industryWhen an EDAA is incorporated into the framework of a peptide or a small moleculeboth substituents attached to thecarbon contribute to the moleculeandapos s shapebiological activity and physical propertiesEDAAs can be used to optimize stabilityclogPand ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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