Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Advanced development of a novel nanoparticle conjugate vaccine for Salmonella Paratyphi A

    SBC: KJ Biosciences LLC            Topic: NIAID

    Salmonella Paratyphi ASParatyphi Ais a major cause of life threatening enteric feverThere is no vaccine available against this pathogenIn the SBIR phase I studieswe have successfully demonstrated the technical feasibility of a novel nanoparticle conjugate vaccine candidate for SParatyphi AIt is based on O polysaccharideOPSantigen conjugated to a novel and highly advantageous nanoparticle protein c ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Multiple Ascending Dose clinical trial of PTI-125, a novel AD therapeutic candidate

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIA

    Project Summary Abstract PTIis a novel small molecule Alzheimerandapos s diseaseADtherapeutic candidate with a novel target and mechanism of actionPTIbinds and reverses an altered conformation of the scaffolding protein filamin AFLNAto prevent Aandapos s tight binding to and toxic signaling via thenicotinic acetylcholine receptornAChRas well as Aandapos s aberrant activation of toll like receptorT ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. CNT-Vectored Delivery of mRNA for HIV-Vaccines

    SBC: LUNA INNOVATIONS INCORPORATED            Topic: NIAID

    Developing safe and effective preventives for HIV remains the hope for controlling the global AIDS epidemicRecentlymRNA vaccines have emerged as a promising alternative to conventional vaccine approaches because of their high potencycapacity for rapid developmentpotential for low cost manufactureTo datethere is no effective mRNA protective vaccine for HIVand the need for one is vastDespite the adv ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A Phase 2b Clinical Trial to Study the Efficacy of Longeveron Mesenchymal Stem Cells (LMSCs) to Treat Aging Frailty

    SBC: Longeveron LLC            Topic: NIA

    Aging Frailty is a biologically driven geriatric syndrome of multisystem physiological decline that is distinct from normal aging and disproportionately increases vulnerability to adverse clinical outcomesFrailty has an overall prevalence ofof thoseyears and olderand there is growing awareness in the geriatric community to diagnose and treat this conditionas it is not an inevitable consequence of ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Preformulation and formulation development of Fenrock, an Abuse-resistant Fentanyl Transdermal Patch

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIDA

    Project Summary Abstract Under this Fast Track proposalwe will develop Fenrockan abuse deterrent transdermal fentanyl patch based on our proprietary co crystal of naltrexoneNTXand its carefully selected conformermethyl furfuralMFFThis NTXMFFco crystalNTX Cohas the desired properties to stay in a crystalline solid form in the patch when applied to skin as intended but to dissociate to deliver NTX w ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Functional integrated human-on-a-chip systems for Alzheimer's research

    SBC: Hesperos, Inc.            Topic: NIA

    Project SummaryThe goal of this proposalat the end of the Phase II effortis to have a service available to academia and industry to screen drugs for Alzheimer s to predict patient outcomes and determine how potential therapeutics are delivered to the CNSThere are currently few companies able to offer multi organ evaluation with a recirculating medium utilizing functional readoutsand none that addr ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. FAST-CMV: A Point-of-Care Cytomegalovirus Serodiagnostic and Avidity Assy

    SBC: LUNA INNOVATIONS INCORPORATED            Topic: NIAID

    Congenital cytomegalovirusCMVinfection is the leading cause of permanent disabilitiescognitive impairmentand sensorineural hearing loss to newbornsMaternal infections that occur during pregnancy and symptomatic congenital CMV infections have been correlated with the most severe complicationsClinical trials are currently evaluating safety and immunogenicity of diverse vaccine candidates driven by t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development and Optimization of MNK Inhibitors for the Treatment of Neuropathic Pain

    SBC: 4E THERAPEUTICS INC.            Topic: 104

    Abstract The goal of this project is to develop an optimized MNK inhibitor for neuropathic pain treatmentMNK is a kinase that phosphorylates eIF E to control the translation of a distinct subset of mRNAsOur focus on this target for neuropathic pain is grounded in evidence that MNK eIF E signaling is activated in nociceptors upon exposure to pain promoting cytokines and growth factors as well as by ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A gel patch for replacing surgical eardrum repair with an office-based procedure

    SBC: Tympanogen, Inc.            Topic: NIDCD

    ABSTRACT Chronic perforations of the tympanic membraneTMaffect overpatients in the United States annuallyoften stemming from ventilation tubes inserted in the TM to drain fluid from middle ear infectionsLeft untreatedthese TM perforations can lead to significant morbidities that include recurrent ear infectionconductive and sensorineural hearing lossmastoid bone infectionand cholesteatoma developm ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Repurposing of Pyrvinium Pamoate for Familial Adenomatous Polyposis (FAP)

    SBC: Stemsynergy Therapeutic            Topic: 102

    ABSTRACT Individuals with the rareinherited disorder Familial Adenomatous PolyposisFAPdevelop thousands of precancerous polyps at an early age and ultimately develop colorectal cancerCRCThe current standard of care for FAP is colectomyHoweverunavoidable side effects of colectomy are debilitatingFurthermorecolectomy does not prevent subsequent development of extra colonic intestinal tumorsthe main ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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