Award Data

In this Phase I SBIR proposal, SandBox Semiconductor™ proposes to develop an Advanced Manufacturing and Material Measurements software tool called Weave ™ for accelerating and automating SEM image analysis for the semiconductor industry. During the development of a new manufacturing process line for a semiconductor device, tens of thousands of scanning electron microscopy (SEM) images are take ...

The goal of medical simulation-based training such as high-fidelity manikin simulators, part task trainers, and screen-based virtual patients, is to approximate real-life treatment experiences without risk to live patients. While the use of sensors has ma

Current strategies for the treatment of osteochondral injuries are ineffective and are associated with significant side effects. Microfracture techniques have demonstrated limited efficacy over long periods of time and are less effective for larger osteochondral defects. Osteochondral autograft transplants require harvesting from a donor site, which can lead to donor site morbidity. Further, while ...

Highly pathogenic alphaviruses like VEEV/EEV/WWEEV cause encephalitis in humans and equids. These infections are endemic in wide regions of the developing world. Translational research regarding these pathogens is focused on developing new strategies to detect, treat and ideally protect humans and animals from these infections. Gene-encoded antibodies against alphavirus E1/E2 surface proteins will ...

The published data has demonstrated that the currently available resuscitation fluids have detrimental effects on trauma outcomes.By addressing these deficiencies it is expected that the outcomes will improve. The crystalloid based resuscitation fluid in development by GanD Inc. has been designed to address all of the shortcomings of the currently available solutions.The solution, GND-001, is a cr ...

Problem: Currently available resuscitation fluids have been shown to induce detrimental effects on trauma outcomes. Objective: The objective of this proposal is to use the data from the successful Phase 1 studies to guide the continued development and te

Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further ...

Joint reduction is a key skill and is a core competency for orthopedic surgeons deploying as part of a trauma team.Current training options are limited to classroom instruction on uninjured persons due to lack of a suitable training simulator. The first true reduction performed by medical providers is on actual patients. This method of instruction prevents the trainee from developing the comfort a ...

Joint reduction is a key skill and is a core competency for orthopedic surgeons deploying as part of a trauma team. Current training options are limited to classroom instruction on uninjured persons due to lack of a suitable training simulator. The first

Over 50,000 American warfighters had been wounded in action in Operations Iraqi and Enduring Freedom (OIF/OEF) with over 1,500 requiring major limb amputations. Warfighters and first responders must have proper tools for pain management during prolonged