Award Data

ABSTRACT Neurodegenerative disordersincluding amyotrophic lateral sclerosisALSFriedreichandapos s ataxiaFAmultiple sclerosisMSDuchenne muscular dystrophyDMDAlzheimer s diseaseADParkinson s diseasePDand Huntington s diseaseHDare characterized by heterogeneous disease progressionEfforts to identify responder subgroups may uncover subgroups that are more homogeneous in disease related features than t ...

Outbreaks have become a significant public threat in hospitalsimpacting both patient lives and creating a financial burdenWith the increasing rise in antibiotic resistancenew interventions are urgently needed to contain ongoing outbreaksRecent studies have confirmed that whole genome sequencingWGSis able to identity unique mutations within each outbreak strainwhich can then be utilized to establis ...

Abstract The U.S. Department of Commerce predicts that STEM (science, technology, engineering, and math) jobs occupations will grow by 8.9 % from 2014 to 2024, compared to 6.4% for non-STEM occupations. STEM wages are generally higher than non-STEM, with a 29% difference in 2015. Yet, current approaches to STEM education are falling significantly short. In 2016, 64% of U.S. high school students un ...

Project Summary This project proposes further development of a computational discovery platform shown to quantifiably identify and prioritize both targets and compounds for therapeutic intervention, which will accelerate the development of newer, more effective drugs with fewer side-effects. This platform is based on a novel fusion of two state of the art computational approaches (phenolog mapping ...

The opioid epidemic in the United States has been traced to aletter reporting in the prestigious New England Journal of Medicine that synthetic opioids are not addictiveA belated citation analysis led the journal to append this letter with a warning this letter has beenheavily and uncritically citedas evidence that addiction is rare with opioid therapyThis epidemic is but one example of how unreli ...

The overall goal of this program is to develop an oral replacement for injecting insulin. The central premise of this work is that a small molecule called BG-148, or similar molecules, can be taken orally in place of injecting insulin to aid in glycemic control. BG-148 could completely replace insulin injections or could reduce insulin injections by half. To begin clinical testing to evaluate this ...

Project Summary Abstract COPD is projected to become the third most common cause of death worldwideand we currently lack any medical therapies that significantly alter the course of this diseaseOur recent work identifies ADAMa disintegin and metalloproteinase domainas the first proteinase that promotes the three key COPD pulmonary pathologiesemphysemasmall airway fibrosisand airway mucus cell meta ...

PROJECT SUMMARY ABSTRACT The human immune response to HIVis complex with the virus demonstrating remarkable evasion mechanismsSignificant progress has recently been made in HIV vaccine development based on early stage clinical trials and subsequent investigations into the nature of protective immunitySeveral promising messenger RNAmRNAbased HIV vaccines that target the HIV envelope proteinEnvhave ...

AbstractGlaucoma is one of a number of optic nerve diseases which lead to retinal ganglion cellsRGCdegenerationultimately manifesting in a functional loss of vision if left untreatedThere exist a number of therapeutic approaches to treat these conditionsbut there are currently no clinical methods to detect the onset of RGC dysfunctionThe Pattern ElectroretinogramPERGis the only established tool to ...

Salmonella Paratyphi ASParatyphi Ais a major cause of life threatening enteric feverThere is no vaccine available against this pathogenIn the SBIR phase I studieswe have successfully demonstrated the technical feasibility of a novel nanoparticle conjugate vaccine candidate for SParatyphi AIt is based on O polysaccharideOPSantigen conjugated to a novel and highly advantageous nanoparticle protein c ...