Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A portable, light-weight, gaspowered, cooling device (PLCD, Portable Limb Cooling Device) for prolonged field damage control of injured ischemic limbs

    SBC: Moveo Walks, Inc.            Topic: DHA182003

    We hypothesize that a combination of advanced insulating fabrics and a cooling method (gas-operated) can be integrated into a portable, light-weight device for field/en route controlled limb cooling.We aim to fabricate a prototype portable device for limb cooling, test its efficacy, and optimize its in preparation of large animal and human trials.The cooling device will consist of a mechanism for ...

    SBIR Phase I 2019 Department of DefenseDefense Health Program
  2. A Biosynthetic Degradable Textile for Soft Tissue Reconstruction

    SBC: Deep Blue Medical Advances, Inc.            Topic: 300

    AbstractBiosynthetic or synthetic degradable hernia mesh is the fastest growing segment of the hernia mesh marketreaching$M in sales inwith Bard controllingof the US marketfollowed by GoreNovus Scientificand EthiconWhile biosynthetic mesh may be used in any type of hernia repairit is most commonly used in ventral hernia repair cases where there is an increased risk of bacterial infectionThe reason ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Ablation of the pathogenic RNA transcript associated with myotonic dystrophy, DM1

    SBC: Enzerna Biosciences LLC            Topic: NIAMS

    ABSTRACTMyotonic muscular dystrophyDMDis a genetic disorder characterized by muscle degeneration and weaknessIt is a common form of muscular dystrophy that generally begins in adulthoodUnfortunatelythere are no approved curative therapies for DMtreatments are largely palliativeThe more severe formmyotonic dystrophy typeDMis caused by theCTG n expansion in theUTR of the dystrophia myotonica protein ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A Clinical Trial Enrichment Tool Based on Subgroups Defined by Machine Learning Predictive Models

    SBC: Origent Data Sciences, Inc.            Topic: 102

    ABSTRACT Neurodegenerative disordersincluding amyotrophic lateral sclerosisALSFriedreichandapos s ataxiaFAmultiple sclerosisMSDuchenne muscular dystrophyDMDAlzheimer s diseaseADParkinson s diseasePDand Huntington s diseaseHDare characterized by heterogeneous disease progressionEfforts to identify responder subgroups may uncover subgroups that are more homogeneous in disease related features than t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. A CLOSED SYSTEM FOR PATHOGEN REDUCTION OF RED BLOOD CELLS FOR TRANSFUSION

    SBC: ZATA PHARMACEUTICALS, INC.            Topic: NHLBI

    ABSTRACT ZATA PharmaceuticalsIncWorcesterMAand NYBCNew YorkNYpropose to develop a closeddisposable pathogen reduction systemZ Systemfor treatment of packed Red Blood CellspRBCfor transfusionThe versatility of the proposed technology allows for several versions of the Z Systems to be createdadapted to different regulatory environmentsand for treatment of whole blood and any of its componentsHowever ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A cloud-based WGS platform for establishing phylogeny within epidemic outbreaks at hospitals

    SBC: ICBiome            Topic: NIAID

    Outbreaks have become a significant public threat in hospitalsimpacting both patient lives and creating a financial burdenWith the increasing rise in antibiotic resistancenew interventions are urgently needed to contain ongoing outbreaksRecent studies have confirmed that whole genome sequencingWGSis able to identity unique mutations within each outbreak strainwhich can then be utilized to establis ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A Comprehensive Newborn Screening Solution for Duchenne and Congenital Muscular Dystrophies

    SBC: Baebies, Inc.            Topic: NICHD

    Congenital genetic abnormalities are a leading cause of childhood mortality and morbidityWhile routine newborn screeningNBShas dramatically improved health outcomesmany congenital disorders such as Duchenne muscular dystrophyDMDand other congenital muscular dystrophiesCMDare not currently detected by routine NBSPresymptomatic identification through NBS is critical to facilitate earlier initiation ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A computational platform to improve the prioritization of drugs and target genes for therapeutic intervention

    SBC: Genetic Networks, LLC            Topic: 100

    Project Summary This project proposes further development of a computational discovery platform shown to quantifiably identify and prioritize both targets and compounds for therapeutic interventionwhich will accelerate the development of newermore effective drugs with fewer side effectsThis platform is based on a novel fusion of two state of the art computational approachesphenolog mapping and fun ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A Custom-Print Adjustable Force Magnetic Device for Severe Blepharoptosis

    SBC: Skelmet, Inc.            Topic: NEI

    Project SummaryAbstract This project aims to determine the technical merit and feasibility of using cranio facial scans to produce a customD printed spectacle device to treat severe ptosisinability to open the eyesThere are many causes of ptosisbut it is most severe and disabling after brainstem strokesevere head traumaand Myasthenia GravisThe devicereferred to as the Magnetic Levator ProsthesisML ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Adaptive & Individualized AAC

    SBC: ALTEC Inc            Topic: NIDCD

    The heterogeneity of the more thanof Americans who suffer from severe physical impairmentsSPIspreclude the use of common augmentative or alternative communicationAACsolutions such as manual signsgestures or dexterous interaction with a touchscreen for communicationWhile efforts to develop alternative access methods through eye or head tracking have provided some communication advancements for thes ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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