Award Data

Congenital genetic abnormalities are a leading cause of childhood mortality and morbidity. While routine newborn screening (NBS) has dramatically improved health outcomes, many congenital disorders such as Duchenne muscular dystrophy (DMD) and other congenital muscular dystrophies (CMD) are not currently detected by routine NBS. Presymptomatic identification through NBS is critical to facilitate e ...

Project Summary This project proposes further development of a computational discovery platform shown to quantifiably identify and prioritize both targets and compounds for therapeutic intervention, which will accelerate the development of newer, more effective drugs with fewer side-effects. This platform is based on a novel fusion of two state of the art computational approaches (phenolog mapping ...

RECENT RESEARCH HAS ESTABLISHED A NEW CLASS OF AUDITORY RESPONSES TERMED OTOACOUSTIC EMISSIONS THAT CAN BE OBJECTIVELY MEASURED IN THE EAR CANAL OF ALL NORMAL HEARING INDIVIDUALS. THUS, IT IS NOW POSSIBLE TO DEVELOP OBJECTIVE HEARING-SCREENING INSTRUMENTS FOR THE ASSESSMENT OF DYSFUNCTION BASED UPON THE ABSENCE OF EMITTED RESPONSES. ONE TYPE OF EMISSION ELICITED BY THE APPLICATION OF CONTINUOUS PU ...

Salmonella Paratyphi ASParatyphi Ais a major cause of life threatening enteric feverThere is no vaccine available against this pathogenIn the SBIR phase I studieswe have successfully demonstrated the technical feasibility of a novel nanoparticle conjugate vaccine candidate for SParatyphi AIt is based on O polysaccharideOPSantigen conjugated to a novel and highly advantageous nanoparticle protein c ...

An estimated 80% of babies born worldwide (approximately 100 million each year) currently do not receive any newborn screening care. Newborn screening (NBS) is an immensely successful testing program that identifies those at increased risk for common, treatable congenital disorders; the pre-symptomatic identification of these disorders in newborns enables the rapid initiation of treatments and red ...

Project Summary:We propose in this SBIR effort to develop a mobile platform based, low-cost, yet highly accurate 3D scanner for audiologists or dispensers to quickly capture ear structure and locally optimize custom-fit hearing aid shell design through rapid prototyping. Hearing loss is the third most prevalent chronic health condition facing seniors. Untreated hearing loss has been shown to lead ...

THE ULTIMATE GOAL OF THIS RESEARCH IS TO DEVELOP A DIAGNOSTIC KIT WHICH WILL PERMIT EASY AND RAPID IDENTIFICATION OF OVARIAN AMYLASE. THIS AMYLASE ISOZYME APPEARS TO BE A GOOD INDICATOR FOR OVARIAN CANCER. IN ADDITION, MONOCLONAL ANTIBODIES WILL BE PRODUCED WHICH WILL ENABLE CLINICAL INVESTIGATORS RELIABLY TO DETECT THE AMOUNTS OF SALIVARY, PANCREATIC, AND OVARIAN AMYLASES IN PATIENT SPECIMENS. IT ...

An Integrated CT-based Image-Guided Neurosurgical System In this SBIR Phase IIb proposal Xoran intends to commercialize a compact and affordable, yet highly- functional, system to provide real time image updates and navigation guidance in support of minimally invasive cranial and spinal neurosurgical procedures. The effort builds on previously developed compact and portable flat-panel Computed Tom ...

Project SummaryImproved methods for the bedside diagnosis and evaluation of neuromuscular disorders are needed. One technology that is finding increasing use for this purpose is electrical impedance myography (EIM). In EIM, a very weak, high frequency electrical current is passed through a muscle of interest and the resulting surface voltages are measured. Disease associated alterations in the com ...

Ventilator-associated pneumonia (VAP) occurs 48–72 hours (or more) following endotracheal intubation and accounts for half of all cases of hospital-acquired pneumonia. CDC reports and many clinical studies point to a critical need for preventing ventilator associated infections rather than fighting an often losing battle against acquired infection. Responding to this unmet need, WynnVision LLC, ...