Award Data

The CONOPS for the Expeditionary Medical Support System (EMEDS) is based on practical effectiveness, speed, and efficiency. Key among the tools required by the Air Mobility Command and the Air Combat Command, which are two of the major commands that are part of the United Air Force is a multi-channel intravenous infusion pump capable of delivering fluids that meets the safe-to-fly criteria for all ...

Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further ...

Phase I has proven that the current setup achieves better than 8mm spatial resolution for 2.2MeV prompt gammas. However, 1mm spatial resolution presents a significant challenge for the current setup due in part to limited timing resolution and count rate. A new analog ASIC will be developed to replace the current analog ASIC that will have better timing resolution and deliver higher count rates. I ...

This project will develop a new scientific instrument optimized for the advanced characterization of near-infrared fluorescent nanoparticles that can exist as left- or right-handed structures (enantiomers). Single-walled carbon nanotubes (SWCNTs) are the leading current example of such nanomaterials. Applied NanoFluorescence, LLC (ANF) proposes a novel multi-mode chiroptical spectrometer that can ...

Cardiovascular toxicityCVTxis a serious short and long term complication of many anti cancer chemotherapeutic regimensZamoranoLancellotti et alIn this PhaseSBIR submission to continue the development and validation of Accel Diagnosticsminimally invasiverapidcost effective and connected blood testthe pScreen CVTx TMfor the early detection and continuous of chemotheropy induced CVTx

Developing safe and effective preventives for HIV remains the hope for controlling the global AIDS epidemicRecentlymRNA vaccines have emerged as a promising alternative to conventional vaccine approaches because of their high potencycapacity for rapid developmentpotential for low cost manufactureTo datethere is no effective mRNA protective vaccine for HIVand the need for one is vastDespite the adv ...

Congenital cytomegalovirusCMVinfection is the leading cause of permanent disabilitiescognitive impairmentand sensorineural hearing loss to newbornsMaternal infections that occur during pregnancy and symptomatic congenital CMV infections have been correlated with the most severe complicationsClinical trials are currently evaluating safety and immunogenicity of diverse vaccine candidates driven by t ...

Salmonella Paratyphi ASParatyphi Ais a major cause of life threatening enteric feverThere is no vaccine available against this pathogenIn the SBIR phase I studieswe have successfully demonstrated the technical feasibility of a novel nanoparticle conjugate vaccine candidate for SParatyphi AIt is based on O polysaccharideOPSantigen conjugated to a novel and highly advantageous nanoparticle protein c ...

O GlcNAcylation of proteins plays a critical role in cell cycle regulationapoptosis and signal transductionModification of O GlcNAcylation of proteins by O GlcNAc transferase is reversible by the activity of O GlcNAcaseAddition and removal of O GlcNAc moiety to serine or threonine regulate the function of proteins directly or via decreased phosphorylationO GlcNAcylation of c myc proteins induces u ...

Project Summary Abstract Under this Fast Track proposalwe will develop Fenrockan abuse deterrent transdermal fentanyl patch based on our proprietary co crystal of naltrexoneNTXand its carefully selected conformermethyl furfuralMFFThis NTXMFFco crystalNTX Cohas the desired properties to stay in a crystalline solid form in the patch when applied to skin as intended but to dissociate to deliver NTX w ...