Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. A Comprehensive Newborn Screening Solution for Duchenne and Congenital Muscular Dystrophies

    SBC: Baebies, Inc.            Topic: NICHD

    Congenital genetic abnormalities are a leading cause of childhood mortality and morbidityWhile routine newborn screeningNBShas dramatically improved health outcomesmany congenital disorders such as Duchenne muscular dystrophyDMDand other congenital muscular dystrophiesCMDare not currently detected by routine NBSPresymptomatic identification through NBS is critical to facilitate earlier initiation ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A computational platform to improve the prioritization of drugs and target genes for therapeutic intervention

    SBC: Genetic Networks, LLC            Topic: 100

    Project Summary This project proposes further development of a computational discovery platform shown to quantifiably identify and prioritize both targets and compounds for therapeutic interventionwhich will accelerate the development of newermore effective drugs with fewer side effectsThis platform is based on a novel fusion of two state of the art computational approachesphenolog mapping and fun ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Advanced development of a novel nanoparticle conjugate vaccine for Salmonella Paratyphi A

    SBC: KJ Biosciences LLC            Topic: NIAID

    Salmonella Paratyphi ASParatyphi Ais a major cause of life threatening enteric feverThere is no vaccine available against this pathogenIn the SBIR phase I studieswe have successfully demonstrated the technical feasibility of a novel nanoparticle conjugate vaccine candidate for SParatyphi AIt is based on O polysaccharideOPSantigen conjugated to a novel and highly advantageous nanoparticle protein c ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. ALow Blood Volume Platform for Global Newborn Screening of Common, Treatable Conditions

    SBC: Baebies, Inc.            Topic: NICHD

    An estimatedof babies born worldwideapproximatelymillion each yearcurrently do not receive any newborn screening careNewborn screeningNBSis an immensely successful testing program that identifies those at increased risk for commontreatable congenital disordersthe pre symptomatic identification of these disorders in newborns enables the rapid initiation of treatments and reduces or prevents serious ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. A Low-Cost and Convenient Solution for Hearing Aid Shell Manufacturing

    SBC: Xyken, LLC            Topic: R

    Project SummaryWe propose in this SBIR effort to develop a mobile platform basedlow costyet highly accurateD scanner for audiologists or dispensers to quickly capture ear structure and locally optimize custom fit hearing aid shell design through rapid prototypingHearing loss is the third most prevalent chronic health condition facing seniorsUntreated hearing loss has been shown to lead to physical ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. An Integrated CT-based Image-Guided Neurosurgical System

    SBC: Xoran Technologies LLC            Topic: 102

    An Integrated CT based Image Guided Neurosurgical System In this SBIR Phase IIb proposal Xoran intends to commercialize a compact and affordableyet highlyfunctionalsystem to provide real time image updates and navigation guidance in support of minimally invasive cranial and spinal neurosurgical proceduresThe effort builds on previously developed compact and portable flat panel Computed TomographyC ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. An integrated electrical impedance myography platform for neuromuscular disease classification and diagnosis

    SBC: Myolex Inc            Topic: 103

    Project SummaryImproved methods for the bedside diagnosis and evaluation of neuromuscular disorders are neededOne technology that is finding increasing use for this purpose is electrical impedance myographyEIMIn EIMa very weakhigh frequency electrical current is passed through a muscle of interest and the resulting surface voltages are measuredDisease associated alterations in the composition and ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Antimicrobial and Biocompatible Endotracheal Tubes

    SBC: Wynnvision LLC            Topic: NHLBI

    Ventilator associated pneumoniaVAPoccurshoursor morefollowing endotracheal intubation and accounts for half of all cases of hospital acquired pneumoniaCDC reports and many clinical studies point to a critical need for preventing ventilator associated infections rather than fighting an often losing battle against acquired infectionResponding to this unmet needWynnVision LLCWVwill leverage strong pr ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A Phase 2b Clinical Trial to Study the Efficacy of Longeveron Mesenchymal Stem Cells (LMSCs) to Treat Aging Frailty

    SBC: Longeveron LLC            Topic: NIA

    Aging Frailty is a biologically driven geriatric syndrome of multisystem physiological decline that is distinct from normal aging and disproportionately increases vulnerability to adverse clinical outcomesFrailty has an overall prevalence ofof thoseyears and olderand there is growing awareness in the geriatric community to diagnose and treat this conditionas it is not an inevitable consequence of ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A Platform for Safe, Noninvasive Prenatal Genetic Testing at Five Weeks of Pregnancy

    SBC: Cradle Genomics, Inc.            Topic: NICHD

    The purpose of this research is to provide a flexible prenatal genetic testing product that can be expanded to detect any inheritable trait as early asand up toweeks of gestationfrom a safenoninvasive Pap smearPublished studiesas well as our own experienceshow that perinatal Pap collections using a cervical cytobrush pose no risk to mother or fetusand captures trophoblast cells that migrate from t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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