Award Data

This project will (i) extend and harden the PSL Editor and the Ontology-Driven XSLT Generator (ODXG) tools and (ii) extend the process description syntax (PDS) derived from the PSL for both KIF and XML/RDF formats. In addition, we will extend the PSL metatheoretical framework to support the PDS and the PSL tools by providing PSL extensions to support calendars and activity specialization, and by d ...

The Phase I and Phase II projects that are the basis for this Phase II enhancement proposal tested the feasibility of releasing opiate compounds from a topical wound dressing for burn pain relief and treatment. This project culminated with a regulatory s

Current thermal and chemical burn care practices such as debridement and physical therapy produce intense pain for patients. The management of this intense pain relies almost exclusively on systemically administered opioids or other pain medications, which are known to produce side effects as serious as opioid dependence.The need to reduce opioid use can be met by delivering the known effective op ...

Problem: Currently available resuscitation fluids have been shown to induce detrimental effects on trauma outcomes. Objective: The objective of this proposal is to use the data from the successful Phase 1 studies to guide the continued development and te

The goal of IPAS is to design and develop Data Integration and Predictive Analysis System (IPAS) that enables prediction, analysis, and response management of incidents of human infectious diseases.IPAS collects and integrates comprehensive datasets of previous disease incidents and potential influencing factors such as environmental, vector prevalence, demographic, health conditions, other diseas ...

Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further ...

Parabon NanoLabs (PNL) has designed and demonstrated the feasibility for a new hybrid vaccine nanostructure that is based upon a DNA origami that can include protein antigens or epitopes, immune stimulators, cell targeting ligands and a transfection plasmid.This approach offers the opportunity for crafting molecularly defined vaccine nanostructures that stimulate a specific primary response that i ...

Joint reduction is a key skill and is a core competency for orthopedic surgeons deploying as part of a trauma team. Current training options are limited to classroom instruction on uninjured persons due to lack of a suitable training simulator. The first

Firefighters have expressed the need for both increased accuracy in fire detection systems and greater access to environmental information in the event of a fire. To accomplish both tasks, Williams-Pyro, Inc. proposes to develop the Smart Environmental Monitoring System (SEMS). This system comprises both an advanced fire detection system and the networking capability necessary to provide real-time ...

Phase I has proven that the current setup achieves better than 8mm spatial resolution for 2.2MeV prompt gammas. However, 1mm spatial resolution presents a significant challenge for the current setup due in part to limited timing resolution and count rate. A new analog ASIC will be developed to replace the current analog ASIC that will have better timing resolution and deliver higher count rates. I ...