Award Data

This project will (i) extend and harden the PSL Editor and the Ontology-Driven XSLT Generator (ODXG) tools and (ii) extend the process description syntax (PDS) derived from the PSL for both KIF and XML/RDF formats. In addition, we will extend the PSL metatheoretical framework to support the PDS and the PSL tools by providing PSL extensions to support calendars and activity specialization, and by d ...

HemoSonics LLC is developing an easy to use and easy to interpret diagnostic device to rapidly identify diffuse coagulopathies in order to guide proper and evidence-based interventions. The management of diffuse coagulopathies is extremely important in military medicine as these conditions represent a significant source of combat morbidity and mortality. HemoSonics device is based on sonorheometry ...

The EPA estimates that one out of every four Americans lives within three miles of a hazardous waste site. Recent advanced materials developments have driven increased use of In Situ Chemical Reduction (ISCR) remediation in the US and globally. Nanoscale Zero Valent Iron (NZVI) holds great potential for ISCR due to its low cost and high capacity for degrading halogenated compounds. However, two ma ...

Realistic surgical simulation requires a combination of representative tissue geometry, accurate tissue material properties and lifelike tool-tissue interaction forces. Recent advances in computational power and imaging modalities have provided the capability to represent the anatomical details required for surgical training; however, the mathematical models which govern the underlying tissue pro ...

The Phase I and Phase II projects that are the basis for this Phase II enhancement proposal tested the feasibility of releasing opiate compounds from a topical wound dressing for burn pain relief and treatment. This project culminated with a regulatory s

Traumatic brain injury (TBI) impacts over two million Americans annually, and is the signature injury of the Iraq and Afghanistan conflicts. Therapeutic hypothermia is a promising neuroprotective technique for treating TBI, but reduced body temperature is a threat to soldiers in military operations with multiple injuries. Mainstream has proposed a novel heat pump cooling system that overcomes the ...

Problem: Currently available resuscitation fluids have been shown to induce detrimental effects on trauma outcomes. Objective: The objective of this proposal is to use the data from the successful Phase 1 studies to guide the continued development and te

Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further ...

Burn injuries to theface present a number of functional and psychological challenges that arisefrom scarring and contracture. Thus, amajor goal of burn and trauma surgeons is to prevent scarring and improvegraftingtechnologies that are used on thecomplextopography of the face. The proposed project builds on previous PhaseII SBIR workthat demonstrated thefeasibility of using a keratin-collagen matr ...

Joint reduction is a key skill and is a core competency for orthopedic surgeons deploying as part of a trauma team. Current training options are limited to classroom instruction on uninjured persons due to lack of a suitable training simulator. The first