Award Data

PROJECT SUMMARY End Stage Renal DiseaseESRDis a complex disease that involves total and permanent kidney failure that affects moreindividuals in the United States aloneHemodialysis is a life sustaining therapy for patients suffering from renal failure that requires that blood be withdrawn and cycled through a dialysis machine that performs the function of the failed kidneysThis process must be rep ...

Congenital genetic abnormalities are a leading cause of childhood mortality and morbidity. While routine newborn screening (NBS) has dramatically improved health outcomes, many congenital disorders such as Duchenne muscular dystrophy (DMD) and other congenital muscular dystrophies (CMD) are not currently detected by routine NBS. Presymptomatic identification through NBS is critical to facilitate e ...

Project Summary This project proposes further development of a computational discovery platform shown to quantifiably identify and prioritize both targets and compounds for therapeutic intervention, which will accelerate the development of newer, more effective drugs with fewer side-effects. This platform is based on a novel fusion of two state of the art computational approaches (phenolog mapping ...

Abstract OsteoarthritisOAremains a significant source of significant pain and disabilityaffecting overmillion adults with an economic burden of over $billion per year to the USJoint replacement is a well established procedurebut its finite life span makes this treatment unacceptable for younger or more active individualswho often require additional revision surgeries as they ageBoth complicated re ...

Salmonella Paratyphi ASParatyphi Ais a major cause of life threatening enteric feverThere is no vaccine available against this pathogenIn the SBIR phase I studieswe have successfully demonstrated the technical feasibility of a novel nanoparticle conjugate vaccine candidate for SParatyphi AIt is based on O polysaccharideOPSantigen conjugated to a novel and highly advantageous nanoparticle protein c ...

An estimated 80% of babies born worldwide (approximately 100 million each year) currently do not receive any newborn screening care. Newborn screening (NBS) is an immensely successful testing program that identifies those at increased risk for common, treatable congenital disorders; the pre-symptomatic identification of these disorders in newborns enables the rapid initiation of treatments and red ...

Project Summary:We propose in this SBIR effort to develop a mobile platform based, low-cost, yet highly accurate 3D scanner for audiologists or dispensers to quickly capture ear structure and locally optimize custom-fit hearing aid shell design through rapid prototyping. Hearing loss is the third most prevalent chronic health condition facing seniors. Untreated hearing loss has been shown to lead ...

Nearlyof adults report drinking alcohol at some point in their life and overreport drinking in the past yearMore importantlynearlyreport past month binge drinkingclose toreport heavy drinkingandmillion people report driving under the influence of alcoholWhile significant numbers of adults report past month risky drinkingof those who drink too much do not meet the criteria for alcohol dependenceAlc ...

PROJECT SUMMARY ABSTRACT This SBIR Phase II project will develop a novel mobile framework to measure left ventricular ejection fraction as a marker for systolic dysfunction using automated non invasive analysis of cardiac signalsHeart disease is the leading cause of death for men and women accounting for more than one thirdof all U SdeathsIntotal costs associated with cardiovascular disease in the ...

ABSTRACT Pediatric injury is the leading cause of child mortality and acquired disability in the United Statesaffectingmillion children annuallyAmong school age children alonemore thanmillion are treated in Emergency Department or admitted to the hospital annually for injuryincurring billions in medical and work loss costs each yearAfter hospital dischargemany injured children experience pain that ...