Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Advanced development of a novel nanoparticle conjugate vaccine for Salmonella Paratyphi A

    SBC: KJ Biosciences LLC            Topic: NIAID

    Salmonella Paratyphi ASParatyphi Ais a major cause of life threatening enteric feverThere is no vaccine available against this pathogenIn the SBIR phase I studieswe have successfully demonstrated the technical feasibility of a novel nanoparticle conjugate vaccine candidate for SParatyphi AIt is based on O polysaccharideOPSantigen conjugated to a novel and highly advantageous nanoparticle protein c ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Multiple Ascending Dose clinical trial of PTI-125, a novel AD therapeutic candidate

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIA

    Project Summary Abstract PTIis a novel small molecule Alzheimerandapos s diseaseADtherapeutic candidate with a novel target and mechanism of actionPTIbinds and reverses an altered conformation of the scaffolding protein filamin AFLNAto prevent Aandapos s tight binding to and toxic signaling via thenicotinic acetylcholine receptornAChRas well as Aandapos s aberrant activation of toll like receptorT ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. CNT-Vectored Delivery of mRNA for HIV-Vaccines

    SBC: LUNA INNOVATIONS INCORPORATED            Topic: NIAID

    Developing safe and effective preventives for HIV remains the hope for controlling the global AIDS epidemicRecentlymRNA vaccines have emerged as a promising alternative to conventional vaccine approaches because of their high potencycapacity for rapid developmentpotential for low cost manufactureTo datethere is no effective mRNA protective vaccine for HIVand the need for one is vastDespite the adv ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. An Innovative Platform for Objective Monitoring of Instrumental Activities of Daily Living

    SBC: BioSensics LLC            Topic: NIA

    With a Phase I II STTR grant award from NIABioSensics in collaboration with Baylor College of MedicineBCMsuccessfully developed and commercialized an advanced physical activity monitoring systemPAMSysfor older adultsPAMSys enables continuous remote monitoring of physical activityfall riskand fall incidentsThe fall detection technology of PAMSys has become the gold standard in the medical alert ind ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. SBIR TOPIC 104, FAST-TRACK, TAPERED GUIDEWIRES FOR TRANSCATHETER ELECTROSURGERY

    SBC: TRANSMURAL SYSTEMS LLC            Topic: NHLBI

    The contractor will develop specific guidewire devices to ease and simplify transcaval access to the aortato make the procedure available to a wider range of patients and operatorsThe goal is to develop a tapered guidewire and a connector switch to a common electrosurgery generator to simplify transcaval access to the aortaUnder Phase I the contractor will develop and test a suite of working proto ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A Phase 2b Clinical Trial to Study the Efficacy of Longeveron Mesenchymal Stem Cells (LMSCs) to Treat Aging Frailty

    SBC: Longeveron LLC            Topic: NIA

    Aging Frailty is a biologically driven geriatric syndrome of multisystem physiological decline that is distinct from normal aging and disproportionately increases vulnerability to adverse clinical outcomesFrailty has an overall prevalence ofof thoseyears and olderand there is growing awareness in the geriatric community to diagnose and treat this conditionas it is not an inevitable consequence of ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Preformulation and formulation development of Fenrock, an Abuse-resistant Fentanyl Transdermal Patch

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIDA

    Project Summary Abstract Under this Fast Track proposalwe will develop Fenrockan abuse deterrent transdermal fentanyl patch based on our proprietary co crystal of naltrexoneNTXand its carefully selected conformermethyl furfuralMFFThis NTXMFFco crystalNTX Cohas the desired properties to stay in a crystalline solid form in the patch when applied to skin as intended but to dissociate to deliver NTX w ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. The Sustainable Heartland Accelerator Regional Partnership (SHARP) Hub

    SBC: BBC Entrepreneurial Training & Consulting, LLC            Topic: 500

    Project Summary Abstract Despite the investment of billions of dollars in biomedical research each year from NIHbarriers remain in effectively translating basic science discoveries from academia to commercial products that benefit patientsThese barriers include a funding gap between basic research and commercial developmentsa lack of knowledge by innovators on how to bring products to marketand a ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Building a commercially scalable bionic pancreas for automated diabetes management

    SBC: Beta Bionics, Inc.            Topic: 200

    Through ayear collaboration between Boston UniversityBUand the Massachusetts General HospitalMGHwe have built insulin only and bihormonalconfigurations of our bionic pancreasBPand extensively tested them in inpatientoutpatientand real world home use studies in people with typediabetesT DWe have also conducted preliminary clinical studies testing the insulin only configuration of our BP in people w ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. High-Resolution, Spinal Cord Stimulation for Non-Opioid Treatment of Neuropathic Pain

    SBC: Micro-Leads, Inc.            Topic: NINDS

    In this SBIR FastTrack proposalMicro Leads will develop HDa high resolutionchannel spinal cord stimulation therapy to provide more pain relief with greater specificity for those suffering from chronic neuropathic pain and opioid dependenceOvermillion in the U Ssuffer from debilitating pain in the trunk and extremities anddepend on opioids to ease their sufferingOpioid abuse has claimed the lives o ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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