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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Populating MPS database with data from multi-organ, human-on-a-chip microphysiological systems

    SBC: HESPEROS, INC            Topic: 100

    Project Summary/Abstract: As stated in the Notice of Special Interest announcement, there is a need to populate the recently established MPS database with existing data generated by organ-on-a-chip systems. Having a centralized, public database with data from all available MPS systems will accelerate development and acceptance of the technology ultimately bringing better therapies to patients fast ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. An Innovative Platform for Objective Monitoring of Instrumental Activities of Daily Living

    SBC: BIOSENSICS LLC            Topic: NIA

    With a Phase I/II STTR grant award from NIA, BioSensics in collaboration with Baylor College of Medicine (BCM) successfully developed and commercialized an advanced physical activity monitoring system (PAMSys™) for older adults. PAMSys enables continuous remote monitoring of physical activity, fall risk, and fall incidents. The fall detection technology of PAMSys has become the gold standard in ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. An Integrated CT-based Image-Guided Neurosurgical System

    SBC: Xoran Technologies LLC            Topic: 102

    An Integrated CT-based Image-Guided Neurosurgical System In this SBIR Phase IIb proposal Xoran intends to commercialize a compact and affordable, yet highly- functional, system to provide real time image updates and navigation guidance in support of minimally invasive cranial and spinal neurosurgical procedures. The effort builds on previously developed compact and portable flat-panel Computed Tom ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A Phase 2b Clinical Trial to Study the Efficacy of Longeveron Mesenchymal Stem Cells (LMSCs) to Treat Aging Frailty

    SBC: Longeveron LLC            Topic: NIA

    Aging Frailty is a biologically driven geriatric syndrome of multisystem physiological decline that is distinct from normal aging and disproportionately increases vulnerability to adverse clinical outcomes. Frailty has an overall prevalence of 10% of those 65 years and older, and there is growing awareness in the geriatric community to diagnose and treat this condition, as it is not an inevitable ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development of VLP vaccine for RSV

    SBC: SIGMOVIR BIOSYSTEMS, INC.            Topic: NIAID

    Respiratory syncytial virus (RSV) is a significant human pathogen severely impacting neonates and young children, but no vaccine exists to protect this vulnerable population. Furthermore, direct vaccination of neonates is likely ineffective due to the immaturity of their immune system, and neonate immunization is potentially unsafe. The current view is that maternal vaccination is the best and saf ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. CFI Pathogen Inactivation of Human Plasma Units

    SBC: APHIOS CORPORATION            Topic: NHLBI

    PROJECT SUMMARY The rapid spread of the Zika virus, which can have a significant impact on neurological disorders in unborn fetuses and potentially adults, the recent outbreak of the extremely virulent Ebola virus, periodic emergence of SARS, recurrent outbreaks of potentially pandemic strains of influenza such as H5N1, the continuing epidemic of MERS and the worldwide AIDS epidemic have highlight ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Increasing size of Phase 2b clinical trial to 60 patients

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIA

    Project Summary/Abstract PTI-125 is a novel small molecule Alzheimer’s disease (AD) therapeutic candidate with a novel target and mechanism of action. PTI-125 binds and reverses an altered conformation of the scaffolding protein filamin A (FLNA) to prevent Aβ42’s tight binding to and toxic signaling via the α7-nicotinic acetylcholine receptor (α7nAChR) as well as Aβ42’s aberrant activati ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Completion of IND-package for a novel, non-narcotic painkiller

    SBC: BLUE THERAPEUTICS, INC.            Topic: NIDA

    Project Summary Opioids like morphine and hydrocodone are generally the most effective therapeutics for treatment of moderate to severe pain. However, their use is limited by serious side effects - tolerance, constipation, respiratory depression, physical dependence and high addictive potential. The frequency of clinical pain, coupled with a lack of alternative therapeutic options has led to a nat ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. The Sustainable Heartland Accelerator Regional Partnership (SHARP) Hub

    SBC: BBC ENTREPRENEURIAL TRAINING & CONSULTING LLC            Topic: 500

    Project Summary/Abstract Despite the investment of billions of dollars in biomedical research each year from NIH, barriers remain in effectively translating basic science discoveries from academia to commercial products that benefit patients. These barriers include a funding gap between basic research and commercial developments, a lack of knowledge by innovators on how to bring products to market ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Functional integrated human-on-a-chip systems for Alzheimer's research

    SBC: HESPEROS, INC            Topic: NIA

    Project SummaryThe goal of this proposal, at the end of the Phase II effort, is to have a service available to academia and industry to screen drugs for Alzheimer’s to predict patient outcomes and determine how potential therapeutics are delivered to the CNS. There are currently few companies able to offer multi-organ evaluation with a recirculating medium utilizing functional readouts, and none ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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