Award Data

In this project, Parabon NanoLabs will employ its Essemblix(tm) Drug Development Platform, a combination of computer-aided design (CAD) software and DNA nano-fabrication technology, to produce artificial vaccines against the biothreat agent ricin on DNA origami decorated first with natural epitopes and ultimately with artificial epitotopes (hereafter"mimotope") constructed from a predefined set of ...

The Phase I and Phase II projects that are the basis for this Phase II enhancement proposal tested the feasibility of releasing opiate compounds from a topical wound dressing for burn pain relief and treatment. This project culminated with a regulatory s

Problem: Currently available resuscitation fluids have been shown to induce detrimental effects on trauma outcomes. Objective: The objective of this proposal is to use the data from the successful Phase 1 studies to guide the continued development and te

Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further ...

Joint reduction is a key skill and is a core competency for orthopedic surgeons deploying as part of a trauma team. Current training options are limited to classroom instruction on uninjured persons due to lack of a suitable training simulator. The first

The CONOPS for the Expeditionary Medical Support System (EMEDS) is based on practical effectiveness, speed, and efficiency. Key among the tools required by the Air Mobility Command and the Air Combat Command, which are two of the major commands that are part of the United Air Force is a multi-channel intravenous infusion pump capable of delivering fluids that meets the safe-to-fly criteria for all ...

The goal of the Environment, Epidemiology, and Etiology Surveillance and Analysis Toolkit (E3SAT) project is to develop a data analysis infrastructure, models and templates to facilitate environmental, epidemiological and etiological analysis. E3SAT provides a research data cube and analysis tool suite that allows researchers to collect, integrate and data mine medical information, environmental ...

There is no capability to rapidly assess the electrical properties of nanofiber films during manufacturing and prepregging process. Continuous monitoring of these films will guide the U.S. nanofiber manufacturing industry in optimizing and increasing the yield rate with proper process optimization and avoid any inconsistency in the process and the cost with associated waste material. To address th ...

The high rate of non-medical Soldiers (Combat Lifesavers and self-aid/buddy-aid) performing field care necessitates additional medical training for those Warfighters. Unfortunately, most non-medical personnel are not provided with opportunities to practic

Limb loss affects approximately 1.9 million people in the United States. It is well established that lower-limb amputees show greater metabolic demands during gait and more limited mobility compared to non-disabled individuals. Currently, there is no lower-extremity prosthesis available that can monitor the metabolic costs of the amputee. The proposed solution, code-named TEQUILA (Total Energy exp ...