Award Data

Project Summary Abstract ObjectiveThis project aims to elevate electron beam therapyEBTtechnologywhich provides effective radiation treatment for superficial cancersdepthandltcmto that of other external beam radiotherapiesXRTe gx rays and protonsby bringing electron intensity modulation into the clinicChallengeApproximatelyof radiotherapy patientsin USA annuallyreceive EBT for a portion of their t ...

This project will provide critical preclinical data for a novel therapeutic small molecule inhibitor of plasminogen activator inhibitorPAIas a potential treatment for diffuse cutaneous systemic sclerosis with associated interstitial lung diseasedcSSc ILDSSc is a devastating disease of unknown etiology with no currently approved disease modifying treatmentslung fibrosisinterstitial lung diseaseILDi ...

PROJECT SUMMARY ABSTRACT Approximatelymillion fractures occur in the United States each yearaccounting forof all musculoskeletal injuries and leading to well overmillion hospital and physician offices visitsUp toof fractures are recalcitrant and require surgical intervention for proper healingThe weakened bones in the growing geriatric population are contributing to the rising number of cases of t ...

PROJECT SUMMARY ABSTRACT This project responds to the need identified by NIDCR to develop improved methods to detect and predict progression of dental cariestooth decayto improve human healthWorldwidecaries is the most common chronic disease affecting almost everyoneDental disease is a major cause of economic and social loss and leads to complications including paintooth loss and even deathGeneral ...

Neonatal hypoxia ischemia is a known cause of cerebral damage resulting from inadequate blood flow and or oxygen delivery to the infant brain beforeduringor after birthThe occurrence among hospital deliveries isperfull term births with a drastic increase among premature newbornsThe deficit in oxygen delivery to the brain results in extensive damage and severe disabilitiesRestoration of blood flow ...

ABSTRACT Individuals with the rareinherited disorder Familial Adenomatous PolyposisFAPdevelop thousands of precancerous polyps at an early age and ultimately develop colorectal cancerCRCThe current standard of care for FAP is colectomyHoweverunavoidable side effects of colectomy are debilitatingFurthermorecolectomy does not prevent subsequent development of extra colonic intestinal tumorsthe main ...

GlioblastomaGBMis the most lethal form of adult brain cancers with a median survival of andltmonths despite aggressive standard chemoradiationGBM are formed by GBM stem like cellsGSCsa major contributor to tumor recurrence and a natural focus for therapeutic developmentThere are two main reasons responsible for treatment failurehigh intraand inter tumor cellular and molecular heterogeneity with mu ...

Project Summary AbstractWe propose to construct multi organ microphysiological systemsBody on a Chipor BoaCsfrom human and rat cells to use as a basis to understand species differences in response to exposure to drugs or chemicals in this new platformThe results will then be compared to clinical datawhere availableand to archived in vivo animal dataThis work will directly test whether such in vitr ...

Project Summary Abstract Despite the investment of billions of dollars in biomedical research each year from NIHbarriers remain in effectively translating basic science discoveries from academia to commercial products that benefit patientsThese barriers include a funding gap between basic research and commercial developmentsa lack of knowledge by innovators on how to bring products to marketand a ...

Project SummaryImproved methods for the bedside diagnosis and evaluation of neuromuscular disorders are neededOne technology that is finding increasing use for this purpose is electrical impedance myographyEIMIn EIMa very weakhigh frequency electrical current is passed through a muscle of interest and the resulting surface voltages are measuredDisease associated alterations in the composition and ...