Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Targeting neurotoxic alpha-synuclein aggregates for Parkinson's disease therapy.

    SBC: Vova Ida, LLC            Topic: 999

    SUMMARYParkinsonandapos s diseasePDis the second most prevalent neurodegenerative disorder after Alzheimerandapos s diseaseADaffecting more thanmillion people in the United StatesBecause age is the major risk factorthe prevalence of both diseases is steadily increasing as our population agesPD belongs to the group of protein misfolding neurodegenerative diseases that are due to the misfolding and ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Next Generation Tools for Onsite Monitoring and Treatment of Drug of Abuse-Dependent Persons

    SBC: SensoDX II, LLC            Topic: NIDA

    Abstract Opioid abuse disorderOADaffectsmillion of Americans annually resulting in overdoses numbering in the tens of thousands and skyrocketing rates of mortalityIn addition to its enormous social impactOAD carries a multi billion dollar price tag that includes $billionspecifically for health care and other costs related to prescription opioid abuse and misuseAlthough effective interventions exis ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Resveratrol as a Corneal Pain Therapeutic

    SBC: TED'S BRAIN SCIENCE INCORPORATED            Topic: N

    More thanindividuals undergo laser vision correction surgery each year in the United Statesincluding laser assisted in situ keratomileusisLASIKand photorefractive keratectomyPRKThese procedures damage the nerves in the corneal epithelium causing intense acute pain that most patients rate as greater thanon ascalemany report the pain to beunbearableeven after analgesic treatmentWhile virtually all p ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Validation of a Cranial Neurosurgery Simulator and Assessment of Minimally Invasive Techniques

    SBC: Simulated Inanimate Models LLC            Topic: 103

    Project SummarySimulation training is unique in its ability for repetitive practice of a wide variety of scenarios and to reflect on performance without jeopardizing a patient s safetySurgical skills simulators have been successful in bridging gaps of the current training modelhoweverthese simulators fall short of offering a complete operative experienceOperative exposure with live patients still ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Molecular Biomarkers of Dangerous Intracranial Aneurysms

    SBC: NEUROVASCULAR DIAGNOSTICS, INC.            Topic: 103

    Abstract Rupture of intracranial aneurysmsIAscauses intracranial hemorrhaging that leads to high rates of neurological deficits and deathAlthough rupture rates are lowclinicians must decide whether to treat or monitor these potentially dangerous lesionsIn the current clinical practicethe most common metric to measure risk of rupture is aneurysm sizemm ormmHoweverclinical data show that small aneur ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A deep learning platform to evaluate the reliability of scientific claims by citation analysis.

    SBC: Scite, Inc.            Topic: NIDA

    The opioid epidemic in the United States has been traced to aletter reporting in the prestigious New England Journal of Medicine that synthetic opioids are not addictiveA belated citation analysis led the journal to append this letter with a warning this letter has beenheavily and uncritically citedas evidence that addiction is rare with opioid therapyThis epidemic is but one example of how unreli ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Transcutaneous auricular neurostimulation for neonatal abstinence syndrome

    SBC: SPARK BIOMEDICAL INC            Topic: R43

    Neonatal abstinence syndromeNASis a condition in which infants undergo withdrawal after exposure to prescription or non prescription opioids such as methadone or heroin in uteroNAS babies exhibit hyperirritability of the central nervous system and respiratorygastrointestinaland autonomic symptomsThese symptoms usually appear withintohours after birthAs ofan infant with NAS was born everyminutes in ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Novel Strategies for Development of a Multiplexed Test with Expanded Content for Spinal Muscular Atrophy

    SBC: ASURAGEN, INC.            Topic: 102

    SummaryThe overall goal of this project is to develop a cost effective multiplexed diagnostic test for spinal muscular atrophySMAto rapidly and accurately analyze multiple classes of disease causingdisease modifying DNA variantsand carrier status markersUltimatelythe proposed test will have a far reaching impact by expanding the identification and stratification of patients who may benefit from ne ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Evaluating the Usability, Efficacy and Commercial Utility of a Digital Platform to Deliver Comprehensive Treatment for Opioid Use Disorder

    SBC: Boulder Care Inc.            Topic: NIDA

    PROJECT SUMMARY Opioid use disorderOUDis a problem of national concernMedication based treatmentMTreduces opioid useassociated risk behaviors and deathDespite evidence supporting MT with buprenorphinein more thanof US countiesmainly ruralthere are no prescribersPatients travel long distancesjoin waitlistsor go without MTOther barriers to care include lack of transportationcompeting demandsworkchil ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. BD2K product for enhancing phenotypic screens

    SBC: GENECENTRIX INC.            Topic: NIDA

    Project Summary! The public health problem addressed by the proposed project is the criticallong term absence of progress in anti addiction medication discovery and developmentGeneCentrixhistoreceptomicstechnology has the potential to alter this trend by providing advanced insights during the process of anti addiction medication discovery and developmentDigital computational advanced insights are ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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