Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Development of a human cellular TBK1 model for drug discovery in ALS

    SBC: Quralis Corporation            Topic: 103

    Program SummaryAmyotrophic lateral sclerosisALSaffects an estimatedindividuals in theUnited States andworldwideThe disease is characterized by loss of motor neurons leadingto loss of muscle control and muscle wastingPatients typically progress from diagnosis todeath inyearsWhile there are two approved therapies to treat ALStheir effectsare limitedThe lack of available treatments for ALS patients r ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A Prescription Digital Therapeutic to Promote Adherence to Buprenorphine Pharmacotherapy for Patients with Opioid Use Disorder

    SBC: Pear Therapeutics, Inc.            Topic: NIDA

    PROJECT SUMMARY ABSTRACT Opioid Use DisorderOUDis a key driver of the current opioid epidemic in the United StatesNearlyof individuals with OUD do not receive treatmentBuprenorphine Medication Assisted TreatmentMATis an effective form of care for OUDBuprenorphine ameliorates craving and withdrawaland reduces illicit opioid usemortalityand problems associated with drug useHoweveradoption of bupreno ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Noninvasive Brain Stimulation for Treating Addiction

    SBC: HIGHLAND INSTRUMENTS            Topic: NIDA

    ProprietaryThis proposal includes trade secrets and other proprietary or confidential information of Highland Instruments and is being provided for use by the National Institutes of HealthNIHfor the sole purpose of evaluating this SBIR proposalNo other rights are conferredThis proposal andthe trade secrets and other proprietary or confidential information contained herein shal further not be discl ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Targeting neurotoxic alpha-synuclein aggregates for Parkinson's disease therapy.

    SBC: Vova Ida, LLC            Topic: 999

    SUMMARYParkinsonandapos s diseasePDis the second most prevalent neurodegenerative disorder after Alzheimerandapos s diseaseADaffecting more thanmillion people in the United StatesBecause age is the major risk factorthe prevalence of both diseases is steadily increasing as our population agesPD belongs to the group of protein misfolding neurodegenerative diseases that are due to the misfolding and ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Next Generation Tools for Onsite Monitoring and Treatment of Drug of Abuse-Dependent Persons

    SBC: SensoDX II, LLC            Topic: NIDA

    Abstract Opioid abuse disorderOADaffectsmillion of Americans annually resulting in overdoses numbering in the tens of thousands and skyrocketing rates of mortalityIn addition to its enormous social impactOAD carries a multi billion dollar price tag that includes $billionspecifically for health care and other costs related to prescription opioid abuse and misuseAlthough effective interventions exis ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Resveratrol as a Corneal Pain Therapeutic

    SBC: TED'S BRAIN SCIENCE INCORPORATED            Topic: N

    More thanindividuals undergo laser vision correction surgery each year in the United Statesincluding laser assisted in situ keratomileusisLASIKand photorefractive keratectomyPRKThese procedures damage the nerves in the corneal epithelium causing intense acute pain that most patients rate as greater thanon ascalemany report the pain to beunbearableeven after analgesic treatmentWhile virtually all p ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Enabling of a Wireless and Remotely Monitored Deep Brain Stimulation System through the Internet of Medical Things for Parkinson's Disease Patients

    SBC: BioNet Sonar            Topic: 103

    Project Summary The objective of this project is to demonstrate feasibility of a novel platform technology using ultrasonic waves for wireless bidirectional real time communication and powering of a Bilateral Deep Brain StimulationDBSsystem with remote patient monitoringDBS has become an established neurosurgical procedure with overpatients treated worldwideDBS has been shown to improve Parkinsona ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Validation of a Cranial Neurosurgery Simulator and Assessment of Minimally Invasive Techniques

    SBC: Simulated Inanimate Models LLC            Topic: 103

    Project SummarySimulation training is unique in its ability for repetitive practice of a wide variety of scenarios and to reflect on performance without jeopardizing a patient s safetySurgical skills simulators have been successful in bridging gaps of the current training modelhoweverthese simulators fall short of offering a complete operative experienceOperative exposure with live patients still ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Long-acting ghrelin for neuropathy

    SBC: Extend Biosciences Inc.            Topic: 103

    Project Summary Neuropathy is an acquired disease that can lead to debilitating chronic pain affectingtoof the general populationAmong patients with symptomatic neuropathysleep disturbancesanxiety and depression are commonnegatively impacting quality of lifeDiabetes is a leading cause of neuropathy and is expected to become more prevalent as the incidence of diabetes increasesChemotherapy induced ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A novel TRP modulator YB-2 to fight opioid crisis and treat chronic pain

    SBC: YOUNG BIOPHARMA, LLC            Topic: NIDA

    Abstract There aremillion people living with chronic pain in the U Swhich is more than the combined prevalence of cancerdiabetes and heart diseaseChronic pain is the number one cause of long term disability in the U STo make matters worsethe prolific use of opioids to treat chronic pain has exacerbated drug abuse and addictionplacing opioid painkillers at the heart of a raging crisis that tookAmer ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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