Award Data

In this Phase I SBIR proposal, SandBox Semiconductor™ proposes to develop an Advanced Manufacturing and Material Measurements software tool called Weave ™ for accelerating and automating SEM image analysis for the semiconductor industry. During the development of a new manufacturing process line for a semiconductor device, tens of thousands of scanning electron microscopy (SEM) images are take ...

Major organ injury such as liver, kidney, heart and lung injuries can lead to high morbidity and mortality in critically ill patients. Advanced noninvasive testing with high sensitivity and specificity is needed to detect specific organ injury particularly at early stages. Current techniques such as PCR, MS, absorption-based assays, ELISA and microfluidic-Luminex, cannot meet such requirements. To ...

Platelets play a central role in hemostasis and are responsible for many inherited and acquired bleeding disorders and thrombic events in human beings. A significant portion of post-trauma deaths are related to coagulopathy or hemorrhage events for both injured soldiers and civilian patients. Several platelet function analyzers have been designed and developed; however due to form-factor and/or ...

Burn injuries constitute 5-20% of combat casualties during conventional warfare. Nonviable tissue within the burn predisposes it to microbial colonization and subsequent infection. The goal of burn care, especially at early echelons, is to control infection until the injury either spontaneously heals or is surgically closed. Prevention of infection is crucial for patient survival and to reduce ...

HemoSonics LLC is developing an easy to use and easy to interpret diagnostic device to rapidly identify diffuse coagulopathies in order to guide proper and evidence-based interventions. The management of diffuse coagulopathies is extremely important in military medicine as these conditions represent a significant source of combat morbidity and mortality. HemoSonics"device is based on sonorheome ...

Sweat contains biomarkers that give an indication of human cognitive levels. In this SBIR project TDA Research is developing a modular sweat sensor patch that has the capability to not only carry out real-time monitoring of select biomarkers, but also to

Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further ...

Bioassays employed to assess the diverse range of toxicity associated with organ injury are time-consuming, costly and require multiple instruments and testing formats (i.e. fluorescence-based capture, ELISAs, PCR, etc.) to reach a diagnosis. These platforms are incapable of predicting the onset of irreversible organ (e.g. kidney, liver, heart and lung) tissue injury. If a single multiplexed scree ...

Veterans with amputations are relatively common as a result of war and peace keeping efforts. The civilian amputee population is also steadily growing as a result of vascular disease. For many years, there has been an emphasis on the development of prosth

Joint reduction is a key skill and is a core competency for orthopedic surgeons deploying as part of a trauma team. Current training options are limited to classroom instruction on uninjured persons due to lack of a suitable training simulator. The first