Award Data

Hyperkalemia continues to be a concern when treating combat casualties. Current hemodialysis systems use a dialysate in a membrane contactor to replicate the function of the kidney by removing the toxins, excess fluid and the minerals. The dialysis machines used in hemodialysis centers are bulky. There are home dialysis machines that are smaller but not person portable and weighing about 70lbs.Sim ...

In this Phase I SBIR proposal, SandBox Semiconductor™ proposes to develop an Advanced Manufacturing and Material Measurements software tool called Weave ™ for accelerating and automating SEM image analysis for the semiconductor industry. During the development of a new manufacturing process line for a semiconductor device, tens of thousands of scanning electron microscopy (SEM) images are take ...

The objective of this Phase I proposal is to develop, design, and prototype a computer-based, Automated Vision Tester (AVT) for comprehensive vision screening of military aircrew. A fully realized AVT would combine a variety of clinical screening tests into a unified, automated tabletop unit capable of conducting screenings at both near (14 in./35 cm) and far (20 ft/6 m) distances. The ideal test ...

The Environmental Protection Agency (EPA) estimates that one out of every four Americans lives within three miles of a hazardous waste site. Recent developments in advanced treatment materials has led to improvements driving increased use of In Situ Chemical Reduction (ISCR) at Superfund sites in the US and other contaminated zones around the world. Nanoscale Zero Valent Iron (NZVI) holds great po ...

Sweat contains biomarkers that give an indication of human cognitive levels. In this SBIR project TDA Research is developing a modular sweat sensor patch that has the capability to not only carry out real-time monitoring of select biomarkers, but also to

Current thermal and chemical burn care practices such as debridement and physical therapy produce intense pain for patients. The management of this intense pain relies almost exclusively on systemically administered opioids or other pain medications, which are known to produce side effects as serious as opioid dependence.The need to reduce opioid use can be met by delivering the known effective op ...

The goal of IPAS is to design and develop Data Integration and Predictive Analysis System (IPAS) that enables prediction, analysis, and response management of incidents of human infectious diseases.IPAS collects and integrates comprehensive datasets of previous disease incidents and potential influencing factors such as environmental, vector prevalence, demographic, health conditions, other diseas ...

Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further ...

Parabon NanoLabs (PNL) has designed and demonstrated the feasibility for a new hybrid vaccine nanostructure that is based upon a DNA origami that can include protein antigens or epitopes, immune stimulators, cell targeting ligands and a transfection plasmid.This approach offers the opportunity for crafting molecularly defined vaccine nanostructures that stimulate a specific primary response that i ...

Veterans with amputations are relatively common as a result of war and peace keeping efforts. The civilian amputee population is also steadily growing as a result of vascular disease. For many years, there has been an emphasis on the development of prosth