Award Data

THE PURPOSE OF THIS STUDY IS THREEFOLD: PART I WILL LAST APPROXIMATELY THREE MONTHS; THE GOAL OF THIS SEGMENT WILL BE TO DEVELOP ALL COMPONENTS REQUIRED FOR A SELF-MANAGEMENT PROGRAM FOR ALL ASTHMATIC PATIENTS. THIS WILL ENTAIL, IN PART, REFINING AND VIDEOTAPING PORTIONS OF A PROGRAM WITH PROVEN EFFICIENCY, WHEEZERS ANONYMOUS. IN ADDITION, RELIABILITY AND VALIDITY OF PAPER-AND-PENCIL INSTRUMENTS U ...

THE DEVELOPMENT OF HUMAN TUMOR COLONY FORMING ASSAYS (HTCFA) HAS OPENED NEW POSSIBILITIES FOR BASIC AND CLINICAL CANCER RESEARCH. HOWEVER, THE PERFORMANCE OF THE DOUBLE-LAYER AGAR TECHNIQUE CURRENTLY USED BY THE MAJORITY OF INVESTIGATORS HAS BEEN GENERALLY LOW. IN THIS CONTRACT, WE PROPOSE THE FURTHER DEVELOPMENT OF AN ALTERNATIVE TECHNIQUE OF TUMOR CELL CLONING USING GLASS CAPILLARY TUBES INSTEAD ...

AMONG THE MAJOR DOSE-LIMITING TOXICITIES OF CURRENTLY USED ANTICANCER DRUGS ARE THOSE AFFECTING THE BONE MARROW, CARDIOVASCULAR SYSTEM, LUNGS, GASTROINTESTINAL TRACT AND THE NERVOUS SYSTEM. HOWEVER, HEMATOTOXICITIES CONSTITUTE THE MOST COMMON AND OFTEN MOST SIGNIFICANT SIDE EFFECT OF THE MAJORITY OF AGENTS. WE PROPOSE THE FURTHER DEVELOPMENT AND CHARACTERIZATION OF IN VITRO SYSTEMS FOR HUMAN MYELO ...

ADVANCES IN MEDICAL CARE HAVE ALLOWED A GREATER NUMBER OF NEONATES TO SURVIVE. THE RESULT HAS BEEN AN INCREASE IN THE NUMBER OF INFANTS AT RISK FOR LATER INTELLECTUAL RETARDATION. HAPPILY, 80 TO 90% OF HIGH-RISK INFANTS ARE INTELLECTUALLY NORMAL LATER IN LIFE. UNFORTUNATELY, NO VALID SCREENING DEVICE FOR DIFFERENTIATING INFANTS WHO WILL LATER BE INTELLECTUALLY NORMAL FROM THOSE WHO WILL BE RETARDE ...

THE SPECIFIC AIM OF THIS PROJECT IS TO DEVELOP TECHNOLOGIC- ALLY EFFICIENT AND COST-EFFECTIVE METHODS FOR THE SEPARATIONAND PURIFICATION OF MULTIGRAM QUANTITIES OF HIGH POLYUN- SATURATES (E.G., EICOSAPNOIC ACID, EPA, C20:5W3; DOCOSAHEXAENOIC ACID, DHA, C22:6W3; AND ESTERS) FROM MARINE/FISH OILS, WITH THE LONG-TERM OBJECTIVE OF MAKING THESE AND POSSIBLY OTHER HIGH POLYUNSATURATES AVAILABLE FOR A WA ...

THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DESIGN A SERUM-FREE CHEMICALLY DEFINED MEDIUM FOR OPTIMUM GROWTH OF MAMMALIAN CELLS IN VITRO. THE SPECIFIC AIM OF THIS PROPOSAL IS TO SOLUBILIZE, BY MEANS OTHER THAN THE USE OF CARRIER PROTEINS, FATTY ACIDS, ALPHA-LIPOIC ACID, FAT-SOLUBLE VITAMINS, AND CHOLESTEROL IN AN EXISTENT SERUM-FREE MEDIUM, CHEE'S ESSENTIAL MEDIUM (CEM). BESIDES HORMONES, GROWTH ...

ACCESSORY APARTMENTS BENEFIT OLDER HOMEOWNERS. THEY CAN PROVIDE INCOME, SECURITY, COMPANIONSHIP, AND A SOURCE OF SERVICES IN RETURN FOR RENT REDUCTIONS. THEY ALSO CREATE INEXPENSIVE RENTAL HOUSING, AND, BECAUSE OF THE BENEFITS LISTED ABOVE, A MEANS TO HELP OLDER HOMEOWNERS AGE IN PLACE.IN CONTRAST, INSTALLATION OF ACCESSORY APARTMENTS IS RARELY SEEN AS A WAY FOR BUSINESS PEOPLE TO MAKE MONEY. AS A ...

WE WILL DETERMINE THE FEASIBILITY OF IMPROVED METHODS FOR DETERMING AIR CONTENT IN FRESH CONCRETE. WE EXPECT THAT A STUDY OF VOLUME CHANGE WITH VARYING PRESSURE AND VACUUM WILL LEAD TO A METHOD THAT WILL INDICATE BOTH AIR CONTENT AND VOID SIZE, AND YIELD AIR CONTENTS THAT T ARE UNAFFECTED BY THE NONTHEORETICAL COMPRESSIBILITY OF SMALL VOIDS. WE WILL DETERMINE THE FEACIBILITY OF SIMPLER METHODS OF ...

DESCRIPTION (provided by applicant): More than 10 million individuals in the U.S. are thought to suffer from diabetic neuropathies. Many serious medical problems stem from this condition, including degradation of the mechanical senses of touch and propri

DESCRIPTION (provided by applicant): Stroke survivors constitute one of the largest groups of patients receiving rehabilitation services in the United States. The inability of most stroke survivors to regain full sensorimotor function significantly imp