Award Data

The SBIR Fast-track develops, tests, and commercializes the ‘Active Disposable Cap for Endoscope (ACE) Tip Stabilization and Complete Visualization and Dissection of Serrated Sessile Polyps.’ The disposable system includes a distal-connecting cap, allowing a clinician to manipulate tissue and perform targeted aspiration during complex polypectomies using proximal controls, without occupying th ...

PROJECT SUMMARY Novel therapies for the treatment of chikungunya virus (CHIKV) infections are urgently needed to address the alarming spread of this pathogen across the Americas. We have identified three distinct series of potent, selective, and orally bioavailable inhibitors of CHIKV replication. In this Phase II renewal SBIR project, we will optimize these series of CHIKV inhibitors to Pre-Devel ...

There is a critical gap in the reliability of anisotropic diffusion magnetic resonance imaging (AdMRI). This gap can be filled by using a ground truth measurement capability that allows for the necessary parametric control of water filled geometries of tubes at the micron scale that can produce paths representative of the millions of axons across centimeters in brain tract trajectories. Diffusion ...

PROJECT SUMMARY ABSTRACT Vocal fold paralysisVFPoccurs when the recurrent laryngeal nerveRLNis injuredmost commonly during surgery of the neckBilateral injury to the RLN can result in potentially life threatening airway obstruction and the need for tracheostomyThe RLN can regenerate some of its axonsbut in many patients with paralysis some form of intervention is required to correct the airway obs ...

Abstract Alzheimer s diseaseADis a progressivedisabling neurodegenerative illness that affects an estimatedmillion people in the United States and approximatelyof the population over the age ofEarly symptoms of the disease include short term memory lossdifficulties with languageand mood swingshoweversymptoms gradually worsen over timeultimately leading to dementia and a loss of bodily functionsSig ...

Project Summary AbstractTraumatic Brain InjuryTBIcontributes to a third of injury related deaths in the US and is among the leading causes of death and disability in people underand overRecent statistics show that TBI annually causesdeathshospital admissionscarries an average lifetime expense of $patientand an annual economic burden conservatively estimated at $billionThe lack of any approved drug ...

PROJECT SUMMARY In pediatric cardiovascular surgery, no commercially available vascular conduit is capable of growing with the patient following implantation. This inability to grow with the patient is particularly relevant for newborns and young children because additional surgeries are required to replace the implanted conduit. In order to address this issue, PECA Labs has developed a novel card ...

Camelid single domain antibody fragmentsVHHpossess a number of distinctive features including a small sizean elevated stabilityand an ability to recognize epitopes non accessible for conventional antibodiesBesides common research and immunotherapy applicationscamelid VHHs are also used as co crystallization chaperonesprotein aggregation controllers and enzyme activity tunersIn this proposalwe wish ...

SUMMARY Acute respiratory tract infections are the leading cause of infectious related mortalitythe fifth leading cause of death overallIn particularrare unrecognized acute respiratory virusARVinfection outbreaks caused many human diseases of unknown etiologyparticularly in less developed countriesIf active ARV infection can be accurately detected and effectively vaccinated or treated with the rig ...

Project Summary PreeclampsiaPEis a pregnancy specific life threatening disorder and one of the leading causes of maternal and fetal morbidity and mortalityIt is responsible for approximatelyof maternal deaths in the US and is the leading cause of intensive care unit admissions in theweeks following deliveryRates of severe PE have tripled sinceThe diagnosis of PE is complicated by heterogeneity in ...